University of Dundee


Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Duffy J, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jiménez-Díaz MB, Jumani RS, Lorimer DD, Love MS, Maher S, Matthews H, McNamara CW, Miller P, O'Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Sharma A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamjar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo F-J, Mäser P, Kyle DE, Winzeler EA, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov AV, Walpole C, Read KD, Van Voorhis WC, Gilbert IH. 2019. Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proceedings of the National Academy of Sciences. 116(14):7015-7020.

Bell M, Foley D, Naylor C, Wood G, Robinson C, Riley J, Epemolu R, Ellis L, Scullion S, Shishikura Y, Osuna-Cabello M, Ferguson L, Pinto E, Fletcher D, Katz E, McLean W, Wyatt P, Read K, Woodland C. 2019. Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1). ACS Medicinal Chemistry Letters. 10(3):341–347.

Boehm C, Field MC. 2019. Evolution of late steps in exocytosis: conservation and specialization of the exocyst complex. Wellcome Open Research. 4:1-19.

Bueno R, Dawson A, Hunter WN. 2019. An assessment of three human methylenetetrahydrofolate dehydrogenase/cyclohydrolase-ligand complexes following further refinement. Acta Crystallographica Section F: Structural Biology Communications. 75(Pt 3):148-152.

Castro GVD, Ciulli A. 2019. Spy vs. Spy: Selecting the best reporter for 19F NMR competition experiment. Chemical Communications. 55(10):1482-1485.

Ciulli A, Farnaby W. 2019. Protein degradation for drug discovery. Drug Discovery Today: Technologies. 31:1-3.

Collett CF, Kitson C, Baker N, Steele-Stallard HB, Santrot M-V, Hutchinson S, Horn D, Alsford S. 2019. Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei. Antimicrobial Agents and Chemotherapy. 63(8):1-19.

Corpas Lopez V, Moniz S, Thomas M, Wall R, Torrie L, Zander-Dinse D, Tinti M, Brand S, Stojanovski L, Manthri S, Hallyburton I, Zuccotto F, Wyatt P, De Rycker M, Horn D, Ferguson M, Clos J, Read K, Fairlamb A, Gilbert I, Wyllie S. 2019. Pharmacological validation of N-myristoyltransferase as a drug target in Leishmania donovani. ACS Infectious Diseases. 5(1):111-122.

Correia Faria J, Glover L, Hutchinson S, Boehm C, Field MC, Horn D. 2019. Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex. Nature Communications. 10:1-14.

Dawson A, Trumper P, de Souza JO, Parker H, Jones MJ, Hales TG, Hunter WN. 2019. Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein. IUCrJ. 6(Part 6):1014-1023.

Diaz Saez L, Torrie L, McElroy S, Gray D, Hunter B. 2019. Burkholderia pseudomallei D-alanine-D-alanine ligase: detailed characterisation and assessment of a potential antibiotic drug target. FEBS Journal.

Ebenezer T, Zoltner M, Burrell A, Nenarokova A, Novák Vanclová AMG, Prasad B, Soukal P, Santana-Molina C, O'Neill E, Nankissoor NN, Vadakedath N, Daiker V, Obado S, Silva-Pereira S, Jackson AP, Devos DP, Lukeš J, Lebert M, Vaughan S, Hampl V, Carrington M, Ginger ML, Dacks JB, Kelly S, Field M. 2019. Transcriptome, proteome and draft genome of Euglena gracilis. BMC Biology. 17:1-23.

Elhaji Y, Sasseville D, Pratt M, Asai Y, Matheson K, McLean WHI, Hull P. 2019. Filaggrin gene loss-of-function mutations constitute a factor in patients with multiple contact allergies. Contact Dermatitis. 80(6):354-358.

Fairlamb AH, Patterson S. 2019. Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis. Current Medicinal Chemistry. 26(23):4454-4475.

Fairlamb A. 2019. Fexinidazole for the treatment of human African trypanosomiasis. Drugs of Today . 55(11):705-712.

Farnaby W, Koegl M, Roy MJ, Whitworth C, Diers E, Trainor N, Zollman D, Steurer S, Karolyi-oezguer J, Riedmueller C, Gmaschitz T, Wachter J, Dank C, Galant M, Sharps B, Rumpel K, Traxler E, Gerstberger T, Schnitzer R, Petermann O, Greb P, Weinstabl H, Bader G, Zoephel A, Weiss-Puxbaum A, Ehrenhöfer-Wölfer K, Wöhrle S, Boehmelt G, Rinnenthal J, Arnhof H, Wiechens N, Wu M-Y, Owen-Hughes T, Ettmayer P, Pearson M, Mcconnell DB, Ciulli A. 2019. Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nature Chemical Biology. 15(8):846.

Fersing C, Basmaciyan L, Boudot C, Pedron J, Hutter S, Cohen A, Castera-Ducros C, Primas N, Laget M, Casanova M, Bourgeade-Delmas S, Piednoel M, Sournia-Saquet A, Belle Mbou V, Courtioux B, Boutet-Robinet É, Since M, Milne R, Wyllie S, Fairlamb AH, Valentin A, Rathelot P, Verhaeghe P, Vanelle P, Azas N. 2019. Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity. ACS Medicinal Chemistry Letters. 10(1):34-39.

Field MC, Rout MP. 2019. Pore timing: the evolutionary origins of the nucleus and nuclear pore complex. F1000Research. 8:1-11.

Field MC. 2019. The kinetochore and the origin of eukaryotic chromosome segregation. Proceedings of the National Academy of Sciences of the United States of America. 116(26):12596-12598.

Ford GA, Lord JM, Ferguson MAJ, Bountra C, Le Couteur DG. 2019. Organizational innovation for developing new medicines that target aging and age-related conditions. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 1-4.

Frost J, Ciulli A, Rocha S. 2019. RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response. Wellcome Open Research. 4:1-17.

Girardini M, Maniaci C, Hughes S, Testa A, Ciulli A. 2019. Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs. Bioorganic & Medicinal Chemistry. 27(12):2466-2479.

Glover L, Marques C, Suska O, Horn D. 2019. Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome. MBio. 10(4):1-17.

Gottschald Chiodi C, Baptista-Hon D, Hunter W, Hales T. 2019. Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA. Journal of Biological Chemistry. 294(7):2375-2385.

Hassell-Hart S, Runcie A, Krojer T, Doyle J, Lineham E, Ocasio CA, Neto BAD, Fedorov O, Marsh G, Maple H, Felix R, Banks R, Ciulli A, Picaud S, Filippakopoulos P, Von Delft F, Brennan P, Stewart HJS, Chevassut TJ, Walker M, Austin C, Morley S, Spencer J. 2019. Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor. Organometallics.

Homeyer N, van Deursen R, Ochoa-Montaño B, Heikamp K, Ray P, Zuccotto F, Blundell TL, Gilbert IH. 2020. A platform for target prediction of phenotypic screening hit molecules. Journal of Molecular Graphics & Modelling. 95:1-9.

Hunter WN, Jones MJ, Dawson A, Hales TG. 2019. A structural rationale for N-methylbicuculline acting as a promiscuous competitive antagonist of inhibitory pentameric ligand gated ion channels. ChemBioChem.

Jabbar-Lopez ZK, Craven J, Logan K, Greenblatt D, Marrs T, Radulovic S, McLean WHI, Lack G, Strachan DP, Perkin MR, Peacock JL, Flohr C. 2019. Longitudinal analysis of the effect of water hardness on atopic eczema: evidence for gene-environment interaction. British Journal of Dermatology.

Kung W-W, Ramachandran S, Makukhin N, Bruno E, Ciulli A. 2019. Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. Nature Communications. 10(1):1-14.

Lim AST, Vincent IM, Barrett MP, Gilbert I. 2019. Small polar hits against S. aureus: Screening, initial hit optimization and metabolomic studies. ACS Omega. 4(21):19199-19215.

Luise N, Wyatt PG. 2019. Diversity-oriented synthesis of bicyclic fragments containing privileged azines. Bioorganic & Medicinal Chemistry Letters. 29(2):248-251.

Luise N, Wyatt EW, Tarver G, Wyatt P. 2019. A Continuous Flow Strategy for the Facile Synthesis and Elaboration of Semi-Saturated Heterobicyclic Fragments. European Journal of Organic Chemistry. 2019(6):1341-1349.

Maniaci C, Ciulli A. 2019. Bifunctional chemical probes inducing protein-protein interactions. Current Opinion in Chemical Biology. 52:145-156.

Martin J, Mackenzie C, Fletcher D, Gilbert I. 2019. Characterising Covalent Warhead Reactivity. Bioorganic & Medicinal Chemistry. 27(10):2066-2074.

Mattos EC, Canuto G, Varón NCM, Magalhães RDM, Crozier TWM, Lamont DJ, Tavares MFM, Colli W, Ferguson MAJ, Alves MJM. 2019. Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix. PLoS Neglected Tropical Diseases. 13(2):1-27.

Moitra S, Pawlowic MC, Hsu F-F, Zhang K. 2019. Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major. Scientific Reports. 9:1-13.

Muha V, Williamson R, Hills R, McNeilly A, McWilliams TG, Alonso J, Schimpl M, Leney AC, Heck AJR, Sutherland C, Read K, McCrimmon R, Brooks SP, van Aalten D. 2019. Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice. Open Biology. 9(11):1-15.

Norcross N, Wilson C, Baragana B, Hallyburton I, Osuna-Cabello M, Norval S, Riley J, Fletcher D, Sinden R, Delves MJ, Ruecker A, Duffy S, Meister S, Antonova-Koch Y, Crespo B, de Cózar C, Sanz L, Gamo F-J, Avery VM, Frearson JA, Gray D, Fairlamb A, Winzeler EA, Waterson D, Campbell SF, Willis P, Read K, Gilbert I. 2019. Substituted Aminoacetamides as Novel Leads for Malaria Treatment. ChemMedChem. 14(14):1329-1335.

Novák Vanclová AMG, Zoltner M, Kelly S, Soukal P, Záhonová K, Füssy Z, Ebenezer TE, Lacová Dobáková E, Eliáš M, Lukeš J, Field MC, Hampl V. 2019. Metabolic quirks and the colourful history of the Euglena gracilis secondary plastid. New Phytologist.

Pankov G, Dawson A, Hunter WN. 2019. The structure of lipopolysaccharide transport protein B (LptB) from Burkholderia pseudomallei. Acta Crystallographica Section F: Structural Biology Communications. 75(4):227-232.

Park Y, Ahn Y-M, Jonnala S, Oh S, Fisher JM, Goodwin MB, Loerger TR, Via LE, Bayliss T, Green SR, Ray PC, Wyatt PG, Barry CE, Boshoff HI. 2019. Inhibition of CorA dependent Magnesium Homeostasis is cidal in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 63(10):1-14.

Pawlowic M, Somepalli M, Sateriale A, Herbert GT, Gibson A, Cuny GD, Hedstrom L, Striepen B. 2019. Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell. Proceedings of the National Academy of Sciences.

Pérez-Moreno G, Sánchez-Carrasco P, Ruiz-Pérez LM, Johansson NG, Müller S, Baragaña B, Hampton SE, Gilbert IH, Kaiser M, Sarkar S, Pandurangan T, Kumar V, González-Pacanowska D. 2019. Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity. Malaria Journal. 18(1):1-12.

Popow J, Arnhof H, Bader G, Berger H, Ciulli A, Covini D, Dank C, Gmaschitz T, Greb P, Karolyi-Özguer J, Koegl M, McConnell DB, Pearson M, Rieger M, Rinnenthal J, Roessler V, Schrenk A, Spina M, Steurer S, Trainor N, Traxler E, Wieshofer C, Zoephel A, Ettmayer P. 2019. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. Journal of Medicinal Chemistry. 62(5):2508–2520.

Prakash O, Führing J, Post J, Shepherd SM, Eadsforth TC, Gray D, Fedorov R, Routier FH. 2019. Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening. Molecules and Cells. 24(5):1-16.

Roy M, Winkler S, Hughes SJ, Whitworth C, Galant M, Farnaby W, Rumpel K, Ciulli A. 2019. SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate. ACS Chemical Biology. 14(3):361-368.

Saura A, Iribarren PA, Rojas-Barros D, Bart JM, López-Farfán D, Andrés-León E, Vidal-Cobo I, Boehm C, Alvarez VE, Field MC, Navarro M. 2019. SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes. EMBO Reports. 1-18.

Shim TN, Brown SJ, Francis ND, Dinneen M, Hawkins D, Muneer A, Minhas S, McLean WHI, Bunker CB. 2019. Male genital lichen sclerosus and filaggrin. Clinical and Experimental Dermatology.

Summers RL, Vanaerschot M, Murithi JM, Pasaje CF, Luth MR, Magistrado-Coxen P, Carpenter EF, Bath J, Pisco JP, Punekar AS, Baragana B, Gilbert IH, Munro JT, Llinas M, Niles JC, Ottilie S, Winzeler EA, Lee MC, Fidock DA, Lukens AK, Wirth DF. 2019. IDENTIFICATION OF THE PLASMODIUM FALCIPARUM ACETYL-COA SYNTHETASE AS AN EMERGING ANTIPLASMODIAL DRUG TARGET. American Journal of Tropical Medicine and Hygiene. 101:476-477.

Testa A, Hughes SJ, Lucas X, Wright JE, Ciulli A. 2019. Structure-Based Design of a Macrocyclic PROTAC. Angewandte Chemie International Edition.

Thomas MG, De Rycker M, Ajakane M, Albrecht S, Álvarez-Pedraglio AI, Boesche M, Brand S, Campbell L, Cantizani-Perez J, Cleghorn LAT, Copley RCB, Crouch SD, Daugan A, Drewes G, Ferrer S, Ghidelli-Disse S, Gonzalez S, Gresham SL, Hill AP, Hindley SJ, Lowe RM, MacKenzie CJ, MacLean L, Manthri S, Martin F, Miguel-Siles J, Nguyen VL, Norval S, Osuna-Cabello M, Woodland A, Patterson S, Pena I, Quesada-Campos MT, Reid IH, Revill C, Riley J, Ruiz-Gomez JR, Shishikura Y, Simeons FRC, Smith A, Smith VC, Spinks D, Stojanovski L, Thomas J, Thompson S, Underwood T, Gray DW, Fiandor JM, Gilbert IH, Wyatt PG, Read KD, Miles TJ. 2019. Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis. Journal of Medicinal Chemistry. 62(3):1180-1202.

Tinti M, Güther MLS, Crozier TWM, Lamond AI, Ferguson MAJ. 2019. Proteome turnover in the bloodstream and procyclic forms of Trypanosoma brucei measured by quantitative proteomics. Wellcome Open Research. 4:1-27.

Torrie L, Zuccotto F, Robinson D, Gray D, Gilbert I, De Rycker M. 2019. Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase. PLoS ONE. 14(5):1-16.

Tovell H, Testa A, Maniaci C, Zhou H, Prescott A, Macartney T, Ciulli A, Alessi D. 2019. Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader. ACS Chemical Biology. 14(5):882-892.

Tovell H, Testa A, Zhou H, Shpiro N, Crafter C, Ciulli A, Alessi D. 2019. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chemical Biology. 14(9):2024-2034.

Trenaman A, Glover L, Hutchinson S, Horn D. 2019. A post-transcriptional respiratome regulon in trypanosomes. Nucleic Acids Research. 47(13):7063-7077.

Velasco RF, Guerrero C, Fra G, Moure A, Miguel-Siles J, Quesada-Campos MT, Ruiz-Gomez JR, Gilbert IH, Thomas MG, Miles TJ. 2019. Optimisation of a Key Cross-Coupling Reaction Towards the Synthesis of a Promising Antileishmanial Compound. Tetrahedron Letters. 60(18):1243-1247.

Wyllie S, Brand S, Thomas M, De Rycker M, Chung C-W, Peña I, Bingham R, Bueren-Calabuig J, Cantizani J, Cebrian D, Craggs PD, Ferguson L, Goswami P, Hobrath J, Howe J, Jeacock L, Ko EJ, Korczynska J, MacLean L, Manthri S, Santos Martinez M, Mata-Cantero L, Moniz S, Nuhs A, Osuna-Cabello M, Pinto E, Riley J, Robinson S, Rowland P, Simeons F, Shishikura Y, Spinks D, Stojanovski L, Thomas J, Thompson S, Viayna Gaza E, Wall R, Zuccotto F, Horn D, Ferguson M, Fairlamb A, Fiandor JM, Martín J, Gray D, Miles TJ, Gilbert I, Read K, Marco M, Wyatt P. 2019. Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition. Proceedings of the National Academy of Sciences. 116(19):9318-9323.,

Zhang S, Sakuma M, Deora GS, Levy CW, Klausing A, Breda C, Read KD, Edlin CD, Ross BP, Wright Muelas M, Day PJ, O'Hagan S, Kell DB, Schwarcz R, Leys D, Heyes DJ, Giorgini F, Scrutton NS. 2019. A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites. Communications Biology. 2:1-10.

Zmuda F, Sastry L, Shepherd SM, Jones D, Scott A, Craggs PD, Cortes A, Gray DW, Torrie LS, De Rycker M. 2019. Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay. Antimicrobial Agents and Chemotherapy. 63(9):1-15.

Zmuda F, Shepherd SM, Ferguson MAJ, Gray DW, Torrie LS, De Rycker M. 2019. Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment. Antimicrobial Agents and Chemotherapy. 63(10):1-11.

Zoppi V, Hughes SJ, Maniaci C, Testa A, Gmaschitz T, Wieshofer C, Koegl M, Riching KM, Daniels DL, Spallarossa A, Ciulli A. 2019. Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7. Journal of Medicinal Chemistry. 62(2):699-726.

EAT Study Team, Marrs T, Logan K, Craven J, Radulovic S, McLean WHI, Lack G, Flohr C, Perkin MR. 2019. Dog ownership at three months of age is associated with protection against food allergy. Allergy.