University of Dundee

Molecular Microbiology 2014

Alonso, J., Schimpl, M. and van Aalten, D. M. (2014) O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling? J Biol Chem. 289, 34433-34439
d.o.i: 10.1074/jbc.R114.609198
PubMed: 4263850
PMC: 25336650

An, S. Q., Allan, J. H., McCarthy, Y., Febrer, M., Dow, J. M. and Ryan, R. P. (2014) The PAS domain-containing histidine kinase RpfS is a second sensor for the diffusible signal factor of Xanthomonas campestris. Mol Microbiol. 92, 586-597
d.o.i: 10.1111/mmi.12577
PubMed: 4159695
PMC: 24617591

An, S. Q., Caly, D. L., McCarthy, Y., Murdoch, S. L., Ward, J., Febrer, M., Dow, J. M. and Ryan, R. P. (2014) Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence. PLoS Pathog. 10, e1004429
d.o.i: 10.1371/journal.ppat.1004429
PubMed: 4199771
PMC: 25329577

Bellini, D., Caly, D. L., McCarthy, Y., Bumann, M., An, S. Q., Dow, J. M., Ryan, R. P. and Walsh, M. A. (2014) Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre. Mol Microbiol. 91, 26-38
d.o.i: 10.1111/mmi.12447
PubMed: 4159591
PMC: 24176013

Borodkin, V. S., Schimpl, M., Gundogdu, M., Rafie, K., Dorfmueller, H. C., Robinson, D. A. and van Aalten, D. M. (2014) Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors. Biochem J. 457, 497-502
d.o.i: 10.1042/BJ20131272
PubMed: 3927924
PMC: 24256146

Bowman, L., Flanagan, L., Fyfe, P. K., Parkin, A., Hunter, W. N. and Sargent, F. (2014) How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase. Biochem J. 458, 449-458
d.o.i: 10.1042/BJ20131520
PubMed: 3940037
PMC: 24428762

Brand, S., Norcross, N. R., Thompson, S., Harrison, J. R., Smith, V. C., Robinson, D. A., Torrie, L. S., McElroy, S. P., Hallyburton, I., Norval, S., Scullion, P., Stojanovski, L., Simeons, F. R. C., van Aalten, D., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Wyatt, P. G., Gilbert, I. H. and Read, K. D. (2014) Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis. Journal of Medicinal Chemistry. 57, 9855-9869
d.o.i: 10.1021/jm500809c
PMC: WOS:000346321200011

Cairns, L. S., Hobley, L. and Stanley-Wall, N. R. (2014) Biofilm formation by Bacillus subtilis: new insights into regulatory strategies and assembly mechanisms. Mol Microbiol. 93, 587-598
d.o.i: 10.1111/mmi.12697
PubMed: 4238804
PMC: 24988880

Cairns, L. S., Marlow, V. L., Kiley, T. B., Birchall, C., Ostrowski, A., Aldridge, P. D. and Stanley-Wall, N. R. (2014) FlgN is required for flagellum-based motility by Bacillus subtilis. J Bacteriol. 196, 2216-2226
d.o.i: 10.1128/JB.01599-14
PubMed: 4054197
PMC: 24706744

Caly, D. L., Coulthurst, S. J., An, S. Q., Helaine, S., Malone, J. G. and Ryan, R. P. (2014) Communication, cooperation, and social interactions: a report from the third Young Microbiologists Symposium on microbe signalling, organisation, and pathogenesis. J Bacteriol. 196, 3527-3533
d.o.i: 10.1128/JB.02029-14
PubMed: 4187693
PMC: 25070739

Dorfmueller, H. C., Ferenbach, A. T., Borodkin, V. S. and van Aalten, D. M. (2014) A structural and biochemical model of processive chitin synthesis. J Biol Chem. 289, 23020-23028
d.o.i: 10.1074/jbc.M114.563353
PubMed: 4132801
PMC: 24942743

Dow, J. M., Grahl, S., Ward, R., Evans, R., Byron, O., Norman, D. G., Palmer, T. and Sargent, F. (2014) Characterization of a periplasmic nitrate reductase in complex with its biosynthetic chaperone. The FEBS journal. 281, 246-260
d.o.i: 10.1111/febs.12592
PubMed: 4159696
PMC: 24314029

English, G., Byron, O., Cianfanelli, F. R., Prescott, A. R. and Coulthurst, S. J. (2014) Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK-TssFG subcomplex. Biochem J. 461, 291-304
d.o.i: 10.1042/BJ20131426
PubMed: 4072051
PMC: 24779861

Gerc, A. J., Stanley-Wall, N. R. and Coulthurst, S. J. (2014) Role of the phosphopantetheinyltransferase enzyme, PswP, in the biosynthesis of antimicrobial secondary metabolites by Serratia marcescens Db10. Microbiology. 160, 1609-1617
d.o.i: 10.1099/mic.0.078576-0
PubMed: 4117218
PMC: 24847000

Gerwig, J., Kiley, T. B., Gunka, K., Stanley-Wall, N. and Stulke, J. (2014) The protein tyrosine kinases EpsB and PtkA differentially affect biofilm formation in Bacillus subtilis. Microbiology. 160, 682-691
d.o.i: 10.1099/mic.0.074971-0
PubMed: 3973450
PMC: 24493247

Gillespie, R. M. and Stanley-Wall, N. R. (2014) Enzymes in action: an interactive activity designed to highlight positive attributes of extracellular enzymes synthesized by microbes. J Microbiol Biol Educ. 15, 310-312
d.o.i: 10.1128/jmbe.v15i2.737
PubMed: 4278508
PMC: 25574303

Hamilton, J. J., Marlow, V. L., Owen, R. A., Costa Mde, A., Guo, M., Buchanan, G., Chandra, G., Trost, M., Coulthurst, S. J., Palmer, T., Stanley-Wall, N. R. and Sargent, F. (2014) A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens. J Cell Biol. 207, 615-626
d.o.i: 10.1083/jcb.201404127
PubMed: 4259817
PMC: 25488919

Hobley, L., Kim, S. H., Maezato, Y., Wyllie, S., Fairlamb, A. H., Stanley-Wall, N. R. and Michael, A. J. (2014) Norspermidine is not a self-produced trigger for biofilm disassembly. Cell. 156, 844-854
d.o.i: 10.1016/j.cell.2014.01.012
PubMed: 3969229
PMC: 24529384

Hopkins, A., Buchanan, G. and Palmer, T. (2014) Role of the twin arginine protein transport pathway in the assembly of the Streptomyces coelicolor cytochrome bc1 complex. J Bacteriol. 196, 50-59
d.o.i: 10.1128/JB.00776-13
PubMed: 3911139
PMC: 24142258

Iguchi, A., Nagaya, Y., Pradel, E., Ooka, T., Ogura, Y., Katsura, K., Kurokawa, K., Oshima, K., Hattori, M., Parkhill, J., Sebaihia, M., Coulthurst, S. J., Gotoh, N., Thomson, N. R., Ewbank, J. J. and Hayashi, T. (2014) Genome evolution and plasticity of Serratia marcescens, an important multidrug-resistant nosocomial pathogen. Genome biology and evolution. 6, 2096-2110
d.o.i: 10.1093/gbe/evu160
PubMed: 4231636
PMC: 25070509

Kneuper, H., Cao, Z. P., Twomey, K. B., Zoltner, M., Jager, F., Cargill, J. S., Chalmers, J., van der Kooi-Pol, M. M., van Dijl, J. M., Ryan, R. P., Hunter, W. N. and Palmer, T. (2014) Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains. Mol Microbiol. 93, 928-943
d.o.i: 10.1111/mmi.12707
PubMed: 4285178
PMC: 25040609

Lockhart, D. E., Schuettelkopf, A., Blair, D. E. and van Aalten, D. M. (2014) Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors. FEBS Lett. 588, 3282-3290
d.o.i: 10.1016/j.febslet.2014.07.015
PubMed: 4158421
PMC: 25063338

Marlow, V. L., Cianfanelli, F. R., Porter, M., Cairns, L. S., Dale, J. K. and Stanley-Wall, N. R. (2014) The prevalence and origin of exoprotease-producing cells in the Bacillus subtilis biofilm. Microbiology. 160, 56-66
d.o.i: 10.1099/mic.0.072389-0
PubMed: 3917226
PMC: 24149708

Marlow, V. L., Porter, M., Hobley, L., Kiley, T. B., Swedlow, J. R., Davidson, F. A. and Stanley-Wall, N. R. (2014) Phosphorylated DegU manipulates cell fate differentiation in the Bacillus subtilis biofilm. J Bacteriol. 196, 16-27
d.o.i: 10.1128/JB.00930-13
PubMed: 3911142
PMC: 24123822

McDowall, J. S., Murphy, B. J., Haumann, M., Palmer, T., Armstrong, F. A. and Sargent, F. (2014) Bacterial formate hydrogenlyase complex. Proc Natl Acad Sci U S A. 111, E3948-3956
d.o.i: 10.1073/pnas.1407927111
PubMed: 4183296
PMC: 25157147

Murphy, B. J., Sargent, F. and Armstrong, F. A. (2014) Transforming an oxygen-tolerant [NiFe] uptake hydrogenase into a proficient, reversible hydrogen producer. Energ Environ Sci. 7, 1426-1433
d.o.i: 10.1039/c3ee43652g
PMC: WOS:000333205800020

Short, F. L., Murdoch, S. L. and Ryan, R. P. (2014) Polybacterial human disease: the ills of social networking. Trends Microbiol. 22, 508-516
d.o.i: 10.1016/j.tim.2014.05.007
PubMed: 4158425
PMC: 24938173

Speakman, C. M., Domke, T. C., Wongpaiboonwattana, W., Sanders, K., Mudaliar, M., van Aalten, D. M., Barton, G. J. and Stavridis, M. P. (2014) Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naive to primed cell transition. Stem cells. 32, 2605-2615
d.o.i: 10.1002/stem.1761
PMC: 24898611

Wulff, P., Day, C. C., Sargent, F. and Armstrong, F. A. (2014) How oxygen reacts with oxygen-tolerant respiratory [NiFe]-hydrogenases. P Natl Acad Sci USA. 111, 6606-6611
d.o.i: 10.1073/pnas.1322393111
PMC: WOS:000335477300035