University of Dundee

Molecular Medicine 2009

Appleyard, M., O'Neill, M. A., Murray, K. E., Paulin, F. E. M., Bray, S. E., Kernohan, N. M., Levison, D. A., Lane, D. P. and Thompson, A. M. (2009) Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model. International Journal of Cancer. 124, 465-472

Arumugam, M., Jun, L. H., Brown, C. J., Lane, D. and Verma, C. (2009) Design of a novel MDM2 binding peptide based on the p53 family. Cell Cycle. 8, 2828-2836

Brown, C. J., Lain, S., Verma, C. S., Fersht, A. R. and Lane, D. P. (2009) Awakening guardian angels: drugging the p53 pathway. Nature Reviews Cancer. 9, 862-873

Brown, C. J., Verma, C. S., Walkinshaw, M. D. and Lane, D. P. (2009) Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site. Cell Cycle. 8, 1905-1911

Brown, S. J. and McLean, W. H. I. (2009) Eczema Genetics: Current State of Knowledge and Future Goals. Journal of Investigative Dermatology. 129, 543-552

Brown, S. J., Relton, C. L., Liao, H., Zhao, Y., Sandilands, A., McLean, W. H. I., Cordell, H. J. and Reynolds, N. J. (2009) Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children. British Journal of Dermatology. 161, 884-889

Chen, H. J., Toh, T. K. L., Szeverenyi, I., Ong, R. T. H., Theng, C. T. S., McLean, W. H. I., Seielstad, M. and Lane, E. B. (2009) Association of Skin Barrier Genes within the PSORS4 Locus Is Enriched in Singaporean Chinese with Early-Onset Psoriasis. Journal of Investigative Dermatology. 129, 606-614

Chen, J., Ng, S. M., Chang, C. Q., Zhang, Z. H., Bourdon, J. C., Lane, D. P. and Peng, J. R. (2009) p53 isoform Delta 113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish. Genes & Development. 23, 278-290

Choong, M. L., Yang, H., Lee, M. A. and Lane, D. P. (2009) Specific activation of the p53 pathway by low dose actinomycin D A new route to p53 based cyclotherapy. Cell Cycle. 8, 2810-2818

Cogulu, O., Onay, H., Aykut, A., Wilson, N. J., Smith, F. J. D., Dereli, T. and Ozkinay, F. (2009) Pachyonychia congenita type 2, N92S mutation of keratin 17 gene: clinical features, mutation analysis and pathological view. European Journal of Pediatrics. 168, 1269-1272

Cordero, M. L., Rolfsnes, H. O., Burnham, D. R., Campbell, P. A., McGloin, D. and Baroud, C. N. (2009) Mixing via thermocapillary generation of flow patterns inside a microfluidic drop. New Journal of Physics. 11

Dayal, S., Sparks, A., Jacob, J., Allende-Vega, N., Lane, D. P. and Saville, M. K. (2009) Suppression of the Deubiquitinating Enzyme USP5 Causes the Accumulation of Unanchored Polyubiquitin and the Activation of p53. Journal of Biological Chemistry. 284, 5030-5041

Fallon, P. G., Sasaki, T., Sandilands, A., Campbell, L. E., Saunders, S. P., Mangan, N. E., Callanan, J. J., Kawasaki, H., Shiohama, A., Kubo, A., Sundberg, J. P., Presland, R. B., Fleckman, P., Shimizu, N., Kudoh, J., Irvine, A. D., Amagai, M. and McLean, W. H. I. (2009) A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nature Genetics. 41, 602-608

Fujita, K., Mondal, A. M., Horikawa, I., Nguyen, G. H., Kumamoto, K., Sohn, J. J., Bowman, E. D., Mathe, E. A., Schetter, A. J., Pine, S. R., Ji, H., Vojtesek, B., Bourdon, J. C., Lane, D. P. and Harris, C. C. (2009) p53 isoforms Delta 133p53 and p53 beta are endogenous regulators of replicative cellular senescence. Nature Cell Biology. 11, 1135-U1208

Gass, J. K., Wilson, N. J., Smith, F. J. D., Lane, E. B., McLean, W. H. I., Rytina, E., Salvary, I. and Burrows, N. P. (2009) Steatocystoma multiplex, oligodontia and partial persistent primary dentition associated with a novel keratin 17 mutation. British Journal of Dermatology. 161, 1396-1398

Gruber, R., Wilson, N. J., Smith, F. J. D., Grabher, D., Steinwender, L., Fritsch, P. O. and Schmuth, M. (2009) Increased pachyonychia congenita severity in patients with concurrent keratin and filaggrin mutations. British Journal of Dermatology. 161, 1391-1395

Hamill, K. J., Langbein, L., Jones, J. C. R. and McLean, W. H. I. (2009) Identification of a Novel Family of Laminin N-terminal Alternate Splice Isoforms STRUCTURAL AND FUNCTIONAL CHARACTERIZATION. Journal of Biological Chemistry. 284, 35588-35596

Hsu, C. K., Akiyama, M., Nemoto-Hasebe, I., Nomura, T., Sandilands, A., Chao, S. C., Lee, J. Y. Y., Sheu, H. M., McLean, W. H. I. and Shimizu, H. (2009) Analysis of Taiwanese ichthyosis vulgaris families further demonstrates differences in FLG mutations between European and Asian populations. British Journal of Dermatology. 161, 448-451

Iorizzo, M., Vincenzi, C., Smith, F. J. D., Wilson, N. J. and Tosti, A. (2009) Pachyonychia Congenita Type I Presenting with Subtle Nail Changes. Pediatric Dermatology. 26, 492-493

Kaspar, R. L., McLean, W. H. I. and Schwartz, M. E. (2009) Achieving successful delivery of nucleic acids to skin: 6th Annual Meeting of the International Pachyonychia Congenita Consortium. J Invest Dermatol. 129, 2085-2087

Lane, D. (2009) Drug discovery in the p53 pathway. Febs Journal. 276, 1-1

Lau, J., Lew, Q. J., Diribarne, G., Michels, A. A., Dey, A., Bensaude, O., Lane, D. P. and Chao, S. H. (2009) Ubiquitination of HEXIM1 by HDM2. Cell Cycle. 8, 2247-2254

Leachman, S. A., Hickerson, R. P., Schwartz, M. E., Bullough, E. E., Hutcherson, S. L., Boucher, K. M., Hansen, C. D., Eliason, M. J., Srivatsa, G. S., Kornbrust, D. J., Smith, F. D., McLean, W., Milstone, L. M. and Kaspar, R. L. (2009) Mutation-specific siRNA resolves callus in a pachyonychia congenita patient. Journal of Investigative Dermatology. 129, 322

Lee, E. W., Lee, M. S., Camus, S., Ghim, J., Yang, M. R., Oh, W., Ha, N. C., Lane, D. P. and Song, J. (2009) Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. Embo Journal. 28, 2100-2113

Liovic, M., D'Alessandro, M., Tomic-Canic, M., Bolshakov, V. N., Coats, S. E. and Lane, E. B. (2009) Severe keratin 5 and 14 mutations induce down-regulation of junction proteins in keratinocytes. Experimental Cell Research. 315, 2995-3003

Madhumalar, A., Jun, L. H., Lane, D. P. and Verma, C. S. (2009) Dimerization of the core domain of the p53 family A computational study. Cell Cycle. 8, 137-148

Medda, F., Russell, R. J. M., Higgins, M., McCarthy, A. R., Campbell, J., Slawin, A. M. Z., Lane, D. P., Lain, S. and Westwood, N. J. (2009) Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity. Journal of Medicinal Chemistry. 52, 2673-2682

Nemoto-Hasebe, I., Akiyama, M., Nomura, T., Sandilands, A., McLean, W. H. I. and Shimizu, H. (2009) Clinical Severity Correlates with Impaired Barrier in Filaggrin-Related Eczema. Journal of Investigative Dermatology. 129, 682-689

Nemoto-Hasebe, I., Akiyama, M., Nomura, T., Sandilands, A., McLean, W. H. I. and Shimizu, H. (2009) FLG mutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema. British Journal of Dermatology. 161, 1387-1390

Neoh, C. Y., Chen, H., Ng, S. K., Lane, E. B. and Common, J. E. A. (2009) A rare connexin 26 mutation in a patient with a forme fruste of keratitis-ichthyosis-deafness (KID) syndrome. International Journal of Dermatology. 48, 1078-1081

Nomura, T., Akiyama, M., Sandilands, A., Nemoto-Hasebe, I., Sakai, K., Nagasaki, A., Palmer, C. N. A., Smith, F. J. D., McLean, W. H. I. and Shimizu, H. (2009) Prevalent and Rare Mutations in the Gene Encoding Filaggrin in Japanese Patients with Ichthyosis Vulgaris and Atopic Dermatitis. Journal of Investigative Dermatology. 129, 1302-1305

Oji, V., Seller, N., Sandilands, A., Gruber, R., Gerss, J., Huffmeier, U. H., Hamm, H., Emmert, S., Aufenvenne, K., Metze, D., Luger, T., Loser, K., Hausser, I., Traupe, H. and McLean, W. H. I. (2009) Ichthyosis vulgaris: novel FLG mutations in the German population and high presence of CD1a+ cells in the epidermis of the atopic subgroup. British Journal of Dermatology. 160, 771-781

O'Regan, G. M., Sandilands, A., McLean, W. H. I. and Irvine, A. D. (2009) Filaggrin in atopic dermatitis (Reprinted from J Allergy Clin Immunol vol 122, pg 689-93, 2008). Journal of Allergy and Clinical Immunology. 124, R2-R6

Pujal, J., Huch, M., Jose, A., Abasolo, I., Rodolosse, A., Duch, A., Sanchez-Palazon, L., Smith, F. J. D., McLean, W. H. I., Fillat, C. and Real, F. X. (2009) Keratin 7 promoter selectively targets transgene expression to normal and neoplastic pancreatic ductal cells in vitro and in vivo. Faseb Journal. 23, 1366-1375

Rodriguez, S., Hall, A. J., Granell, R., McLean, W. H. I., Irvine, A. D., Palmer, C. N. A., Smith, G. D., Henderson, J. and Day, I. N. M. (2009) Carrier Status for the Common R501X and 2282del4 Filaggrin Mutations Is Not Associated with Hearing Phenotypes in 5377 Children from the ALSPAC Cohort. Plos One. 4

Sandilands, A., Sutherland, C., Irvine, A. D. and McLean, W. H. I. (2009) Filaggrin in the frontline: role in skin barrier function and disease. Journal of Cell Science. 122, 1285-1294

Schuttelaar, M. L. A., Kerkhof, M., Jonkman, M. F., Koppelman, G. H., Brunekreef, B., de Jongste, J. C., Wijga, A., McLean, W. H. I. and Postma, D. S. (2009) Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure. Allergy. 64, 1758-1765

Sergeant, A., Campbell, L. E., Hull, P. R., Porter, M., Palmer, C. N. A., Smith, F. J. D., McLean, W. H. I. and Munro, C. S. (2009) Heterozygous Null Alleles in Filaggrin Contribute to Clinical Dry Skin in Young Adults and the Elderly. Journal of Investigative Dermatology. 129, 1042-1045

Sun, M., Li, N., Dong, W., Chen, Z. G., Liu, Q., Xu, Y. M., He, G., Shi, Y. Y., Li, X., Hao, J. J., Luo, Y., Shang, D. D., Lv, D., Ma, F., Zhang, D., Hua, R., Lu, C. X., Wen, Y. R., Cao, L. H., Irvine, A. D., McLean, W. H. I., Dong, Q., Wang, M. R., Yu, J., He, L., Lo, W. H. Y. and Zhang, X. (2009) Copy-Number Mutations on Chromosome 17q24.2-q24.3 in Congenital Generalized Hypertrichosis Terminalis with or without Gingival Hyperplasia. American Journal of Human Genetics. 84, 807-813

Van Limbergen, J., Russell, R. K., Nimmo, E. R., Zhao, Y., Liao, H., Drummond, H. E., Davies, G., Gillett, P. M., McGrogan, P., Bisset, W. M., Mahdi, G., Wilson, D. C., Brown, S. J., McLean, W. H. I. and Satsangi, J. (2009) Filaggrin Loss-of-Function Variants are Associated with Atopic Comorbidity in Pediatric Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 15, 1492-1498

Wan, K. F., Wang, S. F., Brown, C. J., Yu, V. C., Entzeroth, M., Lane, D. P. and Lee, M. A. (2009) Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-X-L. Cell Cycle. 8, 3943-3952

Wen, Y. R., Liu, Y., Xu, Y. M., Zhao, Y. W., Hua, R., Wang, K. B., Sun, M. A., Li, Y. H., Yang, S., Zhang, X. J., Kruse, R., Cichon, S., Betz, R. C., Nothen, M. M., van Steensel, M. A. M., van Geel, M., Steijlen, P. M., Hohl, D., Huber, M., Dunnill, G. S., Kennedy, C., Messenger, A., Munro, C. S., Terrinoni, A., Hovnanian, A., Bodemer, C., de Prost, Y., Paller, A. S., Irvine, A. D., Sinclair, R., Green, J., Shang, D. D., Liu, Q., Luo, Y., Jiang, L., Chen, H. D., Lo, W. H. Y., McLean, W. H. I., He, C. D. and Zhang, X. (2009) Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis (vol 41, pg 228, 2009). Nature Genetics. 41, 762-762

Zamiri, M., Smith, F. J. D., Campbell, L. E., Tetley, L., Eady, R. A. J., Hodgins, M. B., McLean, W. H. I. and Munro, C. S. (2009) Mutation in DSG1 causing autosomal dominant striate palmoplantar keratoderma. British Journal of Dermatology. 161, 692-694