University of Dundee

Molecular Medicine 2008

Avery-Kiejda, K. A., Zhang, X. D., Adams, L. J., Scott, R. J., Vojtesek, B., Lane, D. P. and Hersey, P. (2008). Small molecular weight variants of p53 are expressed in human melanoma cells and are induced by the DNA-damaging agent cisplatin. Clin Cancer Res 14, 1659-68.

Badal, V., Menendez, S., Coomber, D. and Lane, D. P. (2008). Regulation of the p14ARF promoter by DNA methylation. Cell Cycle 7, 112-9.

Basu, K., Palmer, C. N., Lipworth, B. J., Irwin McLean, W. H., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Smith, F. J., Mitra, A. and Mukhopadhyay, S. (2008). Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults. Allergy 63, 1211-7.

Brown, C. J., Srinivasan, D., Jun, L. H., Coomber, D., Verma, C. S. and Lane, D. P. (2008). The electrostatic surface of MDM2 modulates the specificity of its interaction with phosphorylated and unphosphorylated p53 peptides. Cell Cycle 7, 608-10.

Brown, S. J., Relton, C. L., Liao, H., Zhao, Y., Sandilands, A., Wilson, I. J., Burn, J., Reynolds, N. J., McLean, W. H. and Cordell, H. J. (2008). Filaggrin null mutations and childhood atopic eczema: a population-based case-control study. J Allergy Clin Immunol 121, 940-46 e3.

Brown, S. J., Sandilands, A., Zhao, Y., Liao, H., Relton, C. L., Meggitt, S. J., Trembath, R. C., Barker, J. N., Reynolds, N. J., Cordell, H. J. et al. (2008). Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema. J Invest Dermatol 128, 1591-4.

Chen, H., Ho, J. C., Sandilands, A., Chan, Y. C., Giam, Y. C., Evans, A. T., Lane, E. B. and McLean, W. H. (2008). Unique and recurrent mutations in the filaggrin gene in Singaporean Chinese patients with ichthyosis vulgaris. J Invest Dermatol 128, 1669-75.

Chen, H., Toh, T. K., Szeverenyi, I., Ong, R. T., Theng, C. T., McLean, W. H., Seielstad, M. and Lane, E. B. (2008). Association of Skin Barrier Genes within the PSORS4 Locus Is Enriched in Singaporean Chinese with Early-Onset Psoriasis. J Invest Dermatol (in press).

Cogulu, O., Onay, H., Aykut, A., Wilson, N. J., Smith, F. J., Dereli, T. and Ozkinay, F. (2008). Pachyonychia congenita type 2, N92S mutation of keratin 17 gene: clinical features, mutation analysis and pathological view. Eur J Pediatr (in press).

Dastidar, S. G., Lane, D. P. and Verma, C. S. (2008). Multiple peptide conformations give rise to similar binding affinities: molecular simulations of p53-MDM2. J Am Chem Soc 130, 13514-5.

Dayal, S., Sparks, A., Jacob, J., Allende-Vega, N., Lane, D. P. and Saville, M. K. (2008). Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53. J Biol Chem (in press).

Dey, A., Tergaonkar, V. and Lane, D. P. (2008). Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-kappaB pathways. Nat Rev Drug Discov 7, 1031-40.

Dey, A., Verma, C. S. and Lane, D. P. (2008). Updates on p53: modulation of p53 degradation as a therapeutic approach. Br J Cancer 98, 4-8.

Dey, A., Wong, E. T., Cheok, C. F., Tergaonkar, V. and Lane, D. P. (2008). R-Roscovitine simultaneously targets both the p53 and NF-kappaB pathways and causes potentiation of apoptosis: implications in cancer therapy. Cell Death Differ 15, 263-73.

Dodson, G. G., Lane, D. P. and Verma, C. S. (2008). Molecular simulations of protein dynamics: new windows on mechanisms in biology. EMBO Rep 9, 144-50.

Fudge, D., Russell, D., Beriault, D., Moore, W., Lane, E. B. and Vogl, A. W. (2008). The intermediate filament network in cultured human keratinocytes is remarkably extensible and resilient. PLoS ONE 3, e2327.

Gorisch, S. M., Sporbert, A., Stear, J. H., Grunewald, I., Nowak, D., Warbrick, E., Leonhardt, H. and Cardoso, M. C. (2008). Uncoupling the replication machinery: replication fork progression in the absence of processive DNA synthesis. Cell Cycle 7, 1983-90.

Gurumurthy, M., Tan, C. H., Ng, R., Zeiger, L., Lau, J., Lee, J., Dey, A., Philp, R., Li, Q., Lim, T. M. et al. (2008). Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcription. J Mol Biol 378, 302-17.

Hamada, T., Sandilands, A., Fukuda, S., Sakaguchi, S., Ohyama, B., Yasumoto, S., McLean, W. H. and Hashimoto, T. (2008). De novo occurrence of the filaggrin mutation p.R501X with prevalent mutation c.3321delA in a Japanese family with ichthyosis vulgaris complicated by atopic dermatitis. J Invest Dermatol 128, 1323-5.

Henderson, J., Northstone, K., Lee, S. P., Liao, H., Zhao, Y., Pembrey, M., Mukhopadhyay, S., Smith, G. D., Palmer, C. N., McLean, W. H. et al. (2008). The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study. J Allergy Clin Immunol 121, 872-7 e9.

Hickerson, R. P., Smith, F. J., Reeves, R. E., Contag, C. H., Leake, D., Leachman, S. A., Milstone, L. M., McLean, W. H. and Kaspar, R. L. (2008). Single-nucleotide-specific siRNA targeting in a dominant-negative skin model. J Invest Dermatol 128, 594-605.

Janssen, C. O., Lim, S., Lo, E. P., Wan, K. F., Yu, V. C., Lee, M. A., Ng, S. B., Everett, M. J., Buss, A. D., Lane, D. P. and Boyce, R. S. (2008). Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl. Bioorg Med Chem Lett 18, 5771-5773.

Kezic, S., Kemperman, P. M., Koster, E. S., de Jongh, C. M., Thio, H. B., Campbell, L. E., Irvine, A. D., McLean, W. H., Puppels, G. J. and Caspers, P. J. (2008). Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum. J Invest Dermatol 128, 2117-9.

Lain, S., Hollick, J. J., Campbell, J., Staples, O. D., Higgins, M., Aoubala, M., McCarthy, A., Appleyard, V., Murray, K. E., Baker, L. et al. (2008). Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13, 454-63.

Lane, E. B. and McLean, W. H. I. (2008). Broken bricks and cracket mortar - epidermal diseases resulting from genetic abnormalities. Drug Discovery Today (in press).

Leachman, S. A., Hickerson, R. P., Hull, P. R., Smith, F. J., Milstone, L. M., Lane, E. B., Bale, S. J., Roop, D. R., McLean, W. H. and Kaspar, R. L. (2008). Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita. J Dermatol Sci 51, 151-7.

Lee, K. C., Goh, W. L., Xu, M., Kua, N., Lunny, D., Wong, J. S., Coomber, D., Vojtesek, B., Lane, E. B. and Lane, D. P. (2008). Detection of the p53 response in zebrafish embryos using new monoclonal antibodies. Oncogene 27, 629-40.

Liovic, M., Lee, B., Tomic-Canic, M., D'Alessandro, M., Bolshakov, V. N. and Lane, E. B. (2008). Dual-specificity phosphatases in the hypo-osmotic stress response of keratin-defective epithelial cell lines. Exp Cell Res 314, 2066-75.

McGrath, J. A. and McLean, W. H. I. (2008). Genetics in relation to skin. In: Fitzpatrick Dermatology Textbook (7th Edition): Volume 1, Part 2, Biology and Development of Skin; Section 3, Structure and Development of Skin. Chapter 8, pp 73-87. Pub: McGraw-Hill, New York.

McLean, W. H. (2008). Combing the genome for the root cause of baldness. Nat Genet 40, 1270-1.

McLean, W. H., Palmer, C. N., Henderson, J., Kabesch, M., Weidinger, S. and Irvine, A. D. (2008). Filaggrin variants confer susceptibility to asthma. J Allergy Clin Immunol 121, 1294-5; author reply 1295-6.

McLean, W. H. I. (2008). Filaggrin, ichthyosis vulgaris and the architechture of topic dermatitis. Dermatology Focus 26, 1-19.

Motegi, K., Harada, K., Ohe, G., Jones, S. J., Ellis, I. R., Crouch, D. H., Schor, S. L. and Schor, A. M. (2008). Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells. Exp Cell Res 314, 2323-33.

Muller, P., Hrstka, R., Coomber, D., Lane, D. P. and Vojtesek, B. (2008). Chaperone-dependent stabilization and degradation of p53 mutants. Oncogene 27, 3371-83.

Nemoto-Hasebe, I., Akiyama, M., Nomura, T., Sandilands, A., McLean, W. I. and Shimizu, H. (2008). Clinical Severity Correlates with Impaired Barrier in Filaggrin-Related Eczema. J Invest Dermatol (in press).

Nomura, T., Akiyama, M., Sandilands, A., Nemoto-Hasebe, I., Sakai, K., Nagasaki, A., Ota, M., Hata, H., Evans, A. T., Palmer, C. N. et al. (2008). Specific filaggrin mutations cause ichthyosis vulgaris and are significantly associated with atopic dermatitis in Japan. J Invest Dermatol 128, 1436-41.

Nomura ,T., Kodama, K., Moriuchi, R., Yaosaka, M., Kawasaki, H., Abe, M., Sawamura, D. and Shimizu, H. (2008).  Papuloerythroderma of Ofuji associated with eary gastric cancer.  Int J Dermatol 47: 590-1.

Nomura, T., Akiyama, M., Sandilands, A., Nemoto-Hasebe, I., Sakai, K., Nagasaki, A., Palmer, C. N., Smith, F. J., McLean, W. H. and Shimizu, H. (2008). Prevalent and Rare Mutations in the Gene Encoding Filaggrin in Japanese Patients with Ichthyosis Vulgaris and Atopic Dermatitis. J Invest Dermatol (in press).

Oh Adib, C., Jones, B., Liao, H., Smith, F. J., Solomon, R., Egan, C. A. and Leachman, S. (2008). Recurrent mutation in keratin 17 in a large family with pachyonychia congenita type 2. Arch Dermatol Res 300, 211-4.

O'Regan, G. M., Sandilands, A., McLean, W. H. and Irvine, A. D. (2008). Filaggrin in atopic dermatitis. J Allergy Clin Immunol 122, 689-93.

Paulin, F. E., O'Neill, M., McGregor, G., Cassidy, A., Ashfield, A., Ali, C. W., Munro, A. J., Baker, L., Purdie, C. A., Lane, D. P. et al. (2008). MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism. BMC Cancer 8, 281.

Salpingidou, G., Rzepecki, R., Kiseleva, E., Lyon, C., Lane, B., Fusiek, K., Golebiewska, A., Drummond, S., Allen, T., Ellis, J. A. et al. (2008). NEP-A and NEP-B both contribute to nuclear pore formation in Xenopus eggs and oocytes. J Cell Sci 121, 706-16.

Sergeant, A., Campbell, L. E., Hull, P. R., Porter, M., Palmer, C. N., Smith, F. J., McLean, W. H. and Munro, C. S. (2008). Heterozygous Null Alleles in Filaggrin Contribute to Clinical Dry Skin in Young Adults and the Elderly. J Invest Dermatol (in press).

Smith, F. J., Hickerson, R. P., Sayers, J. M., Reeves, R. E., Contag, C. H., Leake, D., Kaspar, R. L. and McLean, W. H. (2008). Development of therapeutic siRNAs for pachyonychia congenita. J Invest Dermatol 128, 50-8.

Staples, O. D., Hollick, J. J., Campbell, J., Higgins, M., McCarthy, A. R., Appleyard, V., Murray, K. E., Baker, L., Thompson, A., Ronseaux, S. et al. (2008). Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen. Cell Cycle 7, 3417-27.

Szeverenyi, I., Cassidy, A. J., Chung, C. W., Lee, B. T., Common, J. E., Ogg, S. C., Chen, H., Sim, S. Y., Goh, W. L., Ng, K. W. et al. (2008). The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases. Hum Mutat 29, 351-60.

Tsubota, A., Akiuama, M., Kanitakis, J., Sakai, K., Nomura, T., Claudy, A. and Shimizu, H. (2008).  Mild recessive bullous congenital ichthyosiform erythroderma due to a previously unidentified homozygous keratin 10 nonsense mutation.  J Invest Dermatol 128: 1648-52.

Weidinger, S., Baurecht, H., Wagenpfeil, S., Henderson, J., Novak, N., Sandilands, A., Chen, H., Rodriguez, E., O'Regan, G. M., Watson, R. et al. (2008). Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk. J Allergy Clin Immunol 122, 560-8 e4.

Weidinger, S., O'Sullivan, M., Illig, T., Baurecht, H., Depner, M., Rodriguez, E., Ruether, A., Klopp, N., Vogelberg, C., Weiland, S. K. et al. (2008). Filaggrin mutations, atopic eczema, hay fever, and asthma in children. J Allergy Clin Immunol 121, 1203-1209 e1.

Xirodimas, D. P. and Lane, D. P. (2008). Targeting a nucleolar SUMO protease for degradation: A mechanism by which ARF induces SUMO conjugation. Cell Cycle 7 (in press).

Zamiri, M., McLean, W. H., Hodgins, M. B. and Munro, C. S. (2008). Pachyonychia congenita type 2: abnormal dentition extending into adulthood. Br J Dermatol 159, 500-1.

Zocchi, L., Bourdon, J. C., Codispoti, A., Knight, R., Lane, D. P., Melino, G. and Terrinoni, A. (2008). Scotin: A new p63 target gene expressed during epidermal differentiation. Biochem Biophys Res Commun 367, 271-6.