University of Dundee

Molecular Physiology 2008

Towler, M.C., Fogarty, S., Hawley, S.A., Pan, D.A., Martin, D.M.A., Morrice, N., McCarthy, A., Galardo, M.N., Merino, S. B., Cigorraga, S.B., Ashworth, A., Sakamoto, K. and Hardie, D.G. (2008) A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. Biochem. J, in press

McGee, S.L., Mustard, K.J., Hardie, D.G. and Baar, K. (2008) Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. J. Physiol. 586, 1731-1741

Robertson, T.P., Mustard, K.J., Lewis, T.H., Wyatt, C.N., Clark, J.H., Peers, C., Hardie, D.G., and Evans, A.M. (2008) AMP-activated protein kinase and hypoxic pulmonary vasoconstriction. Eur. J. Pharmacol. in press

Mooney, M.H., Fogarty, S., Stevenson, C., Gallagher, A.M., Palit, P., Hawley, S.A., Hardie, D.G., Coxon, G.D., Waigh, R.D., Tate, R.J., Harvey, A.L. and Furman, B.L. (2008) Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. Br. J. Pharmacol. 153, 1669-1677

Hardie, D.G. (2008) Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease. FEBS Lett. 582, 81-89

Hardie, D.G. (2008) AMP-activated protein kinase (AMPK). In Encyclopedia of Life Sciences, John Wiley & Sons, Ltd, Chichester

Hardie, D.G. (2008) AMPK and Raptor: matching cell growth to energy supply. Mol.Cell 30, 263-265

Wyatt, C.N., Pearson, S.A., Kumar, P., Peers, C., Hardie, D.G. and Evans, A.M. (2008) Key roles for AMP-activated protein kinase in the function of the carotid body? Adv. Exp. Med. Biol. 605, 63-68

Baar, K. and Hardie, D.G. (2008) Small molecules can have big effects on endurance. Nature Chem. Biol. in press.

Fioretti, B., Trequattrini, C., Sforna, L., Harper, A., Catacuzzeno L, Franciolini F.(2008) Cromakalim activates the K(ATP) and enhances spontaneous transient outward potassium currents in rat saphenous arterial myocytes. Pharmacol Res. 2008 57: 398-402.

Dyavanapalli, J.R., Rimmer, K., and Harper, A.A. (2008) The action of high K+ and aglycemia on the electrical properties and synaptic transmission in rat intracardiac ganglion neurones: in vitro. Exp Physiol (in revision)

Hajduch, E., Turban, S., Le Liepvre, X., Le Lay, S., Dimopoulos, N., Dugail, I. and Hundal. H.S. (2008) Targeting of PKB and PKC to caveolin-enriched microdomains represents a crucial step underpinning ceramide-induced insulin resistance Biochem J 410:369-79.

Green, C.J., Goransson, O., Leslie, N., Gray, A., Alessi, D.R., Sakamoto, K. and Hundal, H.S. (2008) Use of Akti and a drug resistant mutant validates a critical role for PKB in the insulin-dependent regulation of glucose and System A amino acid uptake. J Biol Chem. Jul 31.

Kapacee, Z., Richardson, S.H., Lu, Y., Starborg, T., Holmes, D.F., Baar, K., and Kadler, K.E. (2008) Tension is required for fibripositor formation. Matrix Biology 27:371–375.

McGee, S.L., Mustard, K.J., Hardie, D.G., and Baar, K. (2008) Normal Hypertrophy Accompanied by Phosphoryation and Activation of AMPK-α1 Following Overload in LKB1 Knockout Mice. J Physiol. 586(6):1731-41.

Philp, A., and Baar, K. (2008) Optimising training adaptations by manipulating glycogen. AgroFOOD industry hi-tech 19(2):14-18.

Hamilton, D.L., and Baar, K. (2008) Muscle growth: no IGFs, ands, or buts. J Physiol 1;586(Pt 1):5-6

Baar, K., and McGee, S. (2008) Optimizing training adaptations by manipulating glycogen. European Journal of Sport Science Volume 8, Issue 2, p. 97-106.

Hamilton, D.L., MacKenzie, M.G., and Baar, K. (2008) Molecular mechanisms of skeletal muscle hypertrophy: using molecular biology to understand muscle growth. In: Muscle-Plasticity-Advances in Physiological and Biochemical Research. In Press.

Dennis, R.G., Smith, B., Philp, A., Donnelly, K., and Baar, K. (2008) Bioreactors for guiding muscle tissue growth and development. In: Advances in Biochemical Engineering/Biotechnology: Bioreactor Systems for Tissue Engineering. In Press.

Taylor, P.M. (2008) Amino acid transporters:- éminences grises of nutrient signaling mechanisms? Biochemical Society Transactions in press

MacKenzie, M.G., Hamilton, D.L., Murray, J.T., Taylor, P.M. & Baar, K. (2008) mVps34 is activated following resistance exercise. Submitted to Journal of Physiology