PhD Supervisors

	Supervisor	Projects
	Professor Dario Alessi FRS FRSE Understanding signalling pathways mutated in inherited disorders	Understanding how disruptions in signalling pathways cause human disease Understanding the important role of LRRK2 protein kinase in Parkinson’s disease 3.5 year MRC PhD iCASE Project: Mechanism by which VPS35 controls activity of the LRRK2 Parkinson’s disease kinase Medical Research Scotland studentship: Targeted protein degradation using small molecule as a general approach to probe biology
	Professor Simon Arthur Signaling networks that control inflammation	4 Year MRC PhD Programme: Regulation of T cells via SIK signalling
	Professor Geoff Barton FRSB Protein and nucleic acid sequence analysis and function prediction	4 Year MRC PhD Programme: Prediction of protein specificity determining sites from population genetics 4 Year MRC PhD Studentship: Using bioinformatic, structural and chemical data pools to develop new strategies for fragment and compound optimisation by machine learning methods
	Professor Paul Birch FRSE Plant pathogen interactions	Investigating the roles of Phytophthora infestans virulence factors in promoting late blight disease
	Professor Julian Blow FRSE FMedSci How DNA replication is organised and controlled to ensure precise chromosome duplication	Experimental and theoretical analysis of a novel genome stability pathway How cells prevent under- or over-replication of chromosome segments, and how this affects the pathogenesis of cancer. 4 Year MRC PhD Programme: The development of small molecule inhibitors of replication licensing as novel anti-cancer agents.
	Dr Davide Bulgarelli Structure, function and host control of the plant microbiota	Defining the host genetic determinants of the plant microbiota
	Professor Doreen Cantrell CBE FRS FRSE FMedSci T-lymphocyte signal transduction	4 Year MRC PhD Programme: Regulation of T cells via SIK signalling
	Professor Alessio Ciulli FRSC Chemical and Structural Biology of Protein-Protein Interactions	Manipulating E3 Ubiquitin Ligases with small molecules 3.5 Year MRC PhD iCASE Project: Drugging the undruggable targets through targeted protein degradation. Medical Research Scotland studentship: Targeted protein degradation using small molecule as a general approach to probe biology
	Professor Sir Philip Cohen FRS FRSE FMedSci Signaling Networks that Regulate the Innate Immune System	4 Year MRC PhD Programme: Manipulating myeloid cells to improve cancer immunotherapy.
	Dr Sarah Coulthurst Bacterial pathogens and protein secretion systems	4 Year MRC PhD Programme: Cell biology of a bacterial nano-weapon Building understanding of drug entry into gram negative bacterial
	Professor Victoria Cowling mRNA cap regulation of T cells, embryonic stem cells and cancer cells	Investigating the regulation and therapeutic potential of the mRNA methyl cap mRNA cap function in mammals 4 Year MRC PhD Programme: Investigation of an E3 Ubiquitin Ligase Mutated in Intellectual Disability 4 Year MRC PhD Programme: Role of mRNA cap regulation in embryonic stem cells Investigating mRNA cap regulation in ES cells and T cells
	Dr Kim Dale Establishing the vertebrate embryonic body plan	Mechanistic investigation into the interplay between Notch and Shh signalling in cell fate choice 4 Year MRC PhD Programme: Developing a scalable, high throughput model system for the study of segmentation defects 4 Year MRC PhD Programme: Mathematical modelling of tissue growth and patterning in the presomitic mesoderm: a two coupled oscillator approach.
	Dr Helge Dorfmueller Investigation of cell wall biogenesis in Streptococci	4 Year MRC PhD Programme: Streptococcus pyogenes - Insights into the biosynthesis machinery of a virulence factor
	Professor Mike Ferguson CBE FRS FRSE FMedSci Molecular parasitology, glycobiology and drug discovery	Applying quantitative proteomics to discover new components of glycosylphosphatidylinositol (GPI) biosynthesis. Applying quantitative proteomics to discover new components of glycosylphosphatidylinositol (GPI) biosynthesis. 4 Year MRC PhD Programme: Chagas disease: Understanding parasite tissue tropism and the tissue drug distribution requirements for successful drug development using Mass Spectrometry Imaging (MSI) 3.5 Year MRC PhD Programme iCASE Project: Chagas disease: Understanding parasite tissue tropism and the tissue drug distribution requirements for successful drug development using Mass Spectrometry Imaging (MSI) 4 Year MRC PhD Programme: Streptococcus pyogenes - Insights into the biosynthesis machinery of a virulence factor
	Professor Mark Field Molecular parasitology, intracellular transport, gene expression, eukaryotic evolution	Mechanisms of intracellular transport in trypanosomes 4 Year MRC PhD Programme: Control of gene expression and antigenic variation in trypanosomes
	Professor Geoff Gadd FSB FLS FLSW FRSE Geomicrobiology, Geomycology and Bioremediation	Geomicrobiology and Geomycology - Metal and Mineral Transformations by Fungi Biophysical and biochemical characterization of fungal biominerals
	Dr Ian Ganley Molecular analysis of autophagy	Finding the eat-me signals
	Professor Anton Gartner C. elegans genetics as a model to study basic biological problems	C. elegans a model organism to study human health and disease 4 Year MRC PhD Programme: New mechanisms of branched DNA molecule processing during cytokinesis: Working out the role of the conserved LEM-3 nuclease; from C. elegans to mammals 4 Year MRC PhD Programme: Regulation of cell division by dynamic post-translational modifications New mechanisms of genome maintenance
	Professor Ian Gilbert FRSC Design and synthesis of potential therapeutic agents	*4 Year MRC PhD CASE Studentship: Mode of Action Studies in Kinetoplastids 4 Year MRC PhD Programme: Bacterial efflux pumps and their potential as new targets for antimicrobials Building understanding of drug entry into gram negative bacterial 4 Year MRC PhD Studentship: Using bioinformatic, structural and chemical data pools to develop new strategies for fragment and compound optimisation by machine learning methods
	Dr David Gray Molecular Pharmacology and Compound Screening	4 Year MRC PhD Programme: The development of small molecule inhibitors of replication licensing as novel anti-cancer agents.
	Professor Ron Hay FRS FRSE FMedSci Role of ubiquitin and ubiquitin-like proteins in transcriptional regulation	Structural basis for substrate recognition by the RNF4 ubiquitin E3 ligase Establishing the molecular basis for the therapeutic effect of arsenic trioxide in APL treatment Role of SUMO modification in the response to proteotoxic stress
	Professor Andrew Hopkins FRSC FRSE Chemoinformatics, chemogenomics and drug discovery	Global analysis of drug binding sites
	Professor David Horn FRSE Antigenic variation, drug resistance and RNAi screens in trypanosomes	*4 Year MRC PhD CASE Studentship: Mode of Action Studies in Kinetoplastids 4 Year MRC PhD Programme: Control of gene expression and antigenic variation in trypanosomes
	Professor Hari Hundal FHEA FSB Hormonal, nutrient and stress-mediated modulation of fuel and energy metabolism	Modulation of insulin sensitivity and energy balance in skeletal muscle by the endocannabinoid system
	Professor Bill Hunter FRSE, FMedSci, FRSC Protein structure and function; fundamental chemical biology and early stage antimicrobial drug discovery	Towards the discovery of new modulators of pentameric ligand gated ion channels.
	Dr Jens Januschke Dynamics of cell polarisation	4 Year MRC PhD Programme: Structural and developmental mechanics in polarized membrane trafficking
	Dr. Yogesh Kulathu Ubiquitin signalling mechanisms	4 Year MRC PhD Programme: Signalling pathways regulating intraepithelial lymphocytes in the gut Regulation of protein degradation and homeostasis by the ubiquitin system Mechanisms of substrate recognition by Deubiquitinases Regulation of protein degradation and homeostasis by the ubiquitin system Mechanisms of substrate recognition by Deubiquitinases
	Professor Karim Labib FRSE Roles and regulation of the eukaryotic replisome in preserving genome integrity and epigenetics	Genome stability pathways that regulate the mammalian replisome by ubiquitylation
	Professor Angus Lamond FRS FRSE FMedSci Nuclear structure proteomics and gene expression	4 Year MRC PhD Programme: Quantitative proteomic and cell biological analysis of TGF-b driven tumour promotion in melanoma and squamous cell cancers 4 Year MRC PhD Programme: Deep learning approaches for efficient interpretation of MS peptide spectra.
	Professor David Lilley FRS FRSE FRSC Nucleic acid structure	4 Year MRC PhD Programme: New mechanisms of branched DNA molecule processing during cytokinesis: Working out the role of the conserved LEM-3 nuclease; from C. elegans to mammals New mechanisms of genome maintenance
	Dr Sarah McKim Developmental biology of plant architecture	Regulation of Ideal Plant Architecture in Barley Mechanisms underlying variation in barley hull adhesion
	Dr Miratul Muqit Elucidation of the PINK1 signaling pathway in Parkinson’s disease	Mapping signal transduction pathways in Parkinson’s disease 4 Year MRC PhD Programme: Understanding how the PINK1 kinase targets ubiquitin. 3.5 year MRC PhD iCASE Project: Mechanism by which VPS35 controls activity of the LRRK2 Parkinson’s disease kinase
	Dr Philip Murray	4 Year MRC PhD Programme: Developing a scalable, high throughput model system for the study of segmentation defects 4 Year MRC PhD Programme: Mathematical modelling of tissue growth and patterning in the presomitic mesoderm: a two coupled oscillator approach. 3.5 Year MRC PhD iCASE Project: Real-world assessment of glucose variability and hypoglycaemia in type 1 diabetes in Scotland
	Dr David Norman Magnetic Resonance, FRET, EPR, Spin-labeling and PELDOR	The use of fully deuterated systems for the investigation of membrane associated proteins by EPR
	Professor Tom Owen-Hughes FRSE Chromatin structure and gene regulation	The role of chromatin in gene regulation 4 Year MRC PhD Programme: Single particle cryo-electron microscopy and molecular modelling of chromatin remodelling complexes
	Professor Tracy Palmer FRSE FSB FAAM MEAM Protein Transport in Bacteria	Transport of proteins by the bacterial Tat pathway Regulation and roles in virulence of the type VII protein secretion system of Staphylococcus aureus.
	Dr Mattie Pawlowic	4 Year MRC PhD Programme: Interdisciplinary approach to identifying drug targets and their mode of action in Cryptosporidium Using Mass Spectrometry to Dissect Cryptosporidium
	Dr. Federico Pelisch	4 Year MRC PhD Programme: Regulation of cell division by dynamic post-translational modifications
	Professor Kevin Read Drug discovery, lead optimisation and preclinical development	4 Year MRC PhD Programme: Chagas disease: Understanding parasite tissue tropism and the tissue drug distribution requirements for successful drug development using Mass Spectrometry Imaging (MSI) 3.5 Year MRC PhD Programme iCASE Project: Chagas disease: Understanding parasite tissue tropism and the tissue drug distribution requirements for successful drug development using Mass Spectrometry Imaging (MSI) Building understanding of drug entry into gram negative bacterial
	Professor John Rouse FRSE Control of chromosome stability and DNA repair in health and disease	* SPRINT-MND/MS PhD Programme* Regulation and function of NEK1 kinase in Motor Neurone Disease 4 Year MRC PhD Programme: New mechanisms of branched DNA molecule processing during cytokinesis: Working out the role of the conserved LEM-3 nuclease; from C. elegans to mammals Mechanisms that keep DNA repair nucleases in check
	Dr Adrien Rousseau	Regulation of proteasomal degradation by protein phosphorylation
	Dr Gopal Sapkota Untangling the TGFβ and Wnt signalling networks in cells, development and human diseases	4 Year MRC PhD Programme: Understanding how the PINK1 kinase targets ubiquitin. 3.5 Year MRC PhD iCASE Project: Drugging the undruggable targets through targeted protein degradation. How do FAM83 proteins streamline Casein Kinase 1 (CK1) signalling in cells? Drugging the undruggable with novel proteolytic AdPROM (Affinity-directed PROtein Missile) technology. How do FAM83 proteins streamline Casein Kinase 1 (CK1) signalling in cells? Medical Research Scotland studentship: Targeted protein degradation using small molecule as a general approach to probe biology
	Dr Rastko Sknepnek Computational soft condensed matter and biophysics group	4 Year MRC PhD Programme: The role of Wnt signalling in epithelial cell dynamics during gastrulation in the chick embryo
	Professor Nicola Stanley-Wall FRSE FRSB FEAM Understanding the molecular mechanism of biofilm formation	Molecular analysis of Bacillus subtilis biofilms Molecular analysis of biofilm formation
	Dr Marios Stavridis Pluripotent stem cell biology	4 Year MRC PhD Programme: Investigations into the neuroprotective actions of leptin in models of tauopathy
	Dr. Mahima Swamy Immune interactions at the intestinal epithelium	4 Year MRC PhD Programme: Signalling pathways regulating intraepithelial lymphocytes in the gut Interrogating the functions of intestinal intraepithelial lymphocytes
	Professor Jason Swedlow FRSE Mitotic chromosome dynamics	4 Year MRC PhD Programme: Cell biology of a bacterial nano-weapon
	Professor Tomo Tanaka FRSE Mechanisms ensuring proper chromosome segregation in mitosis	Mechanisms of chromosome segregation in mitosis 4 Year MRC PhD Programme: Mechanisms of chromosome segregation: quantitative and interdisciplinary approaches using nanotechnology and biophysics.
	Professor Daan van Aalten FRSE The role of the O-GlcNAc posttranslational modification in neurodegeneration	Targeting the cell wall of human fungal pathogens The link between O-GlcNAc signalling and neurodevelopmental disease SPRINT-MND/MS PhD Programme Targeting O-GlcNAcylation of periaxin in Charcot-Marie-Tooth type neuropathies 4 Year MRC PhD Programme: Molecular consequences of O-GlcNAc transferase mutations in Intellectual Disability
	Dr Satpal Virdee Chemical Biology Approaches for Studying The Ubiquitin System	Novel chemical tools for studying non-lysine ubiquitination
	Professor Robbie Waugh FRSE Personal Chair of Crop Genomics	Regulation of Ideal Plant Architecture in Barley Mechanisms underlying variation in barley hull adhesion
	Professor Kees Weijer FRSE Cell-cell signalling and chemotactic cell movement during development	4 Year MRC PhD Programme: The role of Wnt signalling in epithelial cell dynamics during gastrulation in the chick embryo
	Professor Paul Wyatt FRSE The discovery of therapeutics for neglected diseases and the translation of novel biology through small molecule drug discovery	4 Year MRC PhD Studentship: Using bioinformatic, structural and chemical data pools to develop new strategies for fragment and compound optimisation by machine learning methods
	Dr Susan Wyllie Kinetoplastid Biology	*4 Year MRC PhD CASE Studentship: Mode of Action Studies in Kinetoplastids 4 Year MRC PhD Programme: Interdisciplinary approach to identifying drug targets and their mode of action in Cryptosporidium
	Ulrich Zachariae Computational Biophysics and Drug Discovery	4 Year MRC PhD Programme: Molecular consequences of O-GlcNAc transferase mutations in Intellectual Disability 4 Year MRC PhD Programme: Bacterial efflux pumps and their potential as new targets for antimicrobials 4 Year MRC PhD Programme: Prediction of protein specificity determining sites from population genetics 4 Year MRC PhD Programme: Single particle cryo-electron microscopy and molecular modelling of chromatin remodelling complexes 4 Year MRC PhD Programme: Machine Learning Approaches in the Quest for New and Better Antimicrobials
	Dr. Fabio Zuccotto	4 Year MRC PhD Studentship: Using bioinformatic, structural and chemical data pools to develop new strategies for fragment and compound optimisation by machine learning methods

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PhD Supervisors

Professor Dario Alessi FRS FRSE

Professor Simon Arthur

Professor Geoff Barton FRSB

Professor Paul Birch FRSE

Professor Julian Blow FRSE FMedSci

Dr Davide Bulgarelli

Professor Doreen Cantrell CBE FRS FRSE FMedSci

Professor Alessio Ciulli FRSC

Professor Sir Philip Cohen FRS FRSE FMedSci

Dr Sarah Coulthurst

Professor Victoria Cowling

Dr Kim Dale

Dr Helge Dorfmueller

Professor Mike Ferguson CBE FRS FRSE FMedSci

Professor Mark Field

Professor Geoff Gadd FSB FLS FLSW FRSE

Dr Ian Ganley

Professor Anton Gartner

Professor Ian Gilbert FRSC

Dr David Gray

Professor Ron Hay FRS FRSE FMedSci

Professor Andrew Hopkins FRSC FRSE

Professor David Horn FRSE

Professor Hari Hundal FHEA FSB

Professor Bill Hunter FRSE, FMedSci, FRSC

Dr Jens Januschke

Dr. Yogesh Kulathu

Professor Karim Labib FRSE

Professor Angus Lamond FRS FRSE FMedSci

Professor David Lilley FRS FRSE FRSC

Dr Sarah McKim

Dr Miratul Muqit

Dr Philip Murray

Dr David Norman

Professor Tom Owen-Hughes FRSE

Professor Tracy Palmer FRSE FSB FAAM MEAM

Dr Mattie Pawlowic

Dr. Federico Pelisch

Professor Kevin Read

Professor John Rouse FRSE

Dr Adrien Rousseau

Dr Gopal Sapkota

Dr Rastko Sknepnek

Professor Nicola Stanley-Wall FRSE FRSB FEAM

Dr Marios Stavridis

Dr. Mahima Swamy

Professor Jason Swedlow FRSE

Professor Tomo Tanaka FRSE

Professor Daan van Aalten FRSE

Dr Satpal Virdee

Professor Robbie Waugh FRSE

Professor Kees Weijer FRSE

Professor Paul Wyatt FRSE

Dr Susan Wyllie

Ulrich Zachariae

Dr. Fabio Zuccotto