University of Dundee

Wellcome 4-Year PhD Programme in Integrated Molecular, Cellular and Translational Biology

The Wellcome Trust Integrated molecular, cellular and translational biology programme combines scientific excellence with a commitment to improving the working environment and transition support for trainees. This PhD programme, provided by world-renowned scientists from the School of Life Sciences at the University of Dundee, will train the next generation of scientists at the forefront of international science. Students will join our supportive and positive research culture with the opportunity to select research projects centred around four themes:

  1. Cellular Regulation
  2. Protein Modification
  3. Infection and Immunity
  4. Drug Discovery and Translation

Around 50 different potential supervisors will participate in this programme 

Dr Jens Jansuchke

How do cells become different from each other? One way to achieve this fundamental process is through asymmetric division, when a cell divides resulting in two cells of different fate. For instance, asymmetric divisions of stem cells occur in the developing nervous system of many different species including fruit flies and humans. Intriguingly, disrupting the correct specification of cell types by interfering with asymmetric stem cell divisions can trigger tumor-like growth. How then are different cell fates established through asymmetric division and how does this prevent uncontrolled tumor-like growth? Our research will use the powerful genetics of Drosophila, coupled with state of the art live cell microscopy and chemical genetics approaches to uncover the molecular mechanism that normally regulate asymmetric cell division of stem cells in the developing nervous system of the fly. There will also be a particular focus on exploring the role and regulation of kinases and protein phosphorylation in the context of cell polarity establishment and cell fate generation.