University of Dundee

Wellcome 4-Year PhD Programme in Integrated Molecular, Cellular and Translational Biology

The Wellcome Trust Integrated molecular, cellular and translational biology programme combines scientific excellence with a commitment to improving the working environment and transition support for trainees. This PhD programme, provided by world-renowned scientists from the School of Life Sciences at the University of Dundee, will train the next generation of scientists at the forefront of international science. Students will join our supportive and positive research culture with the opportunity to select research projects centred around four themes:

  1. Cellular Regulation
  2. Protein Modification
  3. Infection and Immunity
  4. Drug Discovery and Translation

Around 50 different potential supervisors will participate in this programme

Prof Doreen Cantrell

The research program adopts a multidisciplinary approach and combines biochemistry, cell biology and in vivo mouse immunology to map how antigen receptor, cytokine and environmental signals integrate to control the function of T lymphocytes.  One important component of the work is a discovery based program to use high resolution mass spectrometry to systematically define how changes in environment modulate the  proteomes of naïve and effector CD4 and CD8 T lymphocyte subpopulations. Specifically, we will comprehensively delineate the molecular details of how changing the supply of nutrients impacts T cell signal transduction pathways and T cell phenotype. These experiments will identify the molecular processes that determine T cell fate outcomes.