University of Dundee

Wellcome 4-Year PhD Programme in Integrated Molecular, Cellular and Translational Biology

The Wellcome Trust Integrated molecular, cellular and translational biology programme combines scientific excellence with a commitment to improving the working environment and transition support for trainees. This PhD programme, provided by world-renowned scientists from the School of Life Sciences at the University of Dundee, will train the next generation of scientists at the forefront of international science. Students will join our supportive and positive research culture with the opportunity to select research projects centred around four themes:

  1. Cellular Regulation
  2. Protein Modification
  3. Infection and Immunity
  4. Drug Discovery and Translation

Around 50 different potential supervisors will participate in this programme

Dr Andrei Pisliakov

Proteins in a living cell act as molecular machines that carry out specific functions, e.g. catalyse biochemical reactions, move ligands across biological membranes, mediate signalling, etc. The overall goal of our research is to understand the biomolecular function and underlying mechanisms of proteins by using the (physics-based) modelling and simulation methods. The work is done in close collaboration with our experimental colleagues, with occasional applications in drug discovery. Our current work focusses on (i) allosteric regulation of enzymes that control regulated gene expression; (ii) effects of post-translational modifications on protein-protein interactions; (iii) proton transfer processes in membrane proteins