The Wellcome Trust Integrated molecular, cellular and translational biology programme combines scientific excellence with a commitment to improving the working environment and transition support for trainees. This PhD programme, provided by world-renowned scientists from the School of Life Sciences at the University of Dundee, will train the next generation of scientists at the forefront of international science. Students will join our supportive and positive research culture with the opportunity to select research projects centred around four themes:
- Cellular Regulation
- Protein Modification
- Infection and Immunity
- Drug Discovery and Translation
Around 50 different potential supervisors will participate in this programme.
Professor Julian Blow:
The aim of our work is to understand at a molecular level the way that chromosome replication is regulated, and to apply this knowledge to improving the diagnosis and treatment of cancer. We use a number of two main model systems to study cell cycle control of DNA replication. Cell-free extracts of Xenopus eggs, which support all the nuclear events of the early embryonic cell cycle, provide a powerful system for studying DNA replication control at a biochemical level. We also use human tissue culture cells which have important advantages for studying DNA replication using cell biological and molecular genetic approaches. Current research projects are addressing: a) how the licensing system is regulated at different stages of the cell division cycle; b) how the Cdc7 and cyclin-dependent kinases trigger the initiation of DNA replication; c) how replication origins are physically organised on chromosomal DNA; and d) the potential of small molecule inhibitors of replication licensing to provide a novel anti-cancer treatment.