University of Dundee

CSC - Phosphorylation of Rab GTPases in Health & Disease

Phosphorylation is a major posttranslational modification whose disruption is linked to multiple human diseases. Our lab has recently found a link between the Parkinson’s associated protein kinase PINK1 and a subset of Rab GTPases. This project will employ state-of-the-art methods to uncover the regulation of Rabs by PINK1 in cells .

The project will lead to training in a wide array of technologies including mass spectrometry and biochemistry. The lab is also linked to the EMBO network and the student will also benefit from training opportunities in Europe during their studies.

1. Vieweg et al., BioRxiv 2019. 764019

2. Lai et al., EMBO J, 2015 34: 2840.