University of Dundee

China Scholarship Council PhD programme - Non-lysine Deubiquitination

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

Ubiquitination is a posttranslational modification carried out by E3 ligases that regulates all aspects of physiology and aberrant ubiquitination has been implicated with numerous diseases.  Ubiquitination is typically considered a posttranslational modification of lysine residues. Our lab has recently established that non-lysine ubiquitination might be much more prevalent than initially thought and could serve distinct functions in both health and disease. We have identified E3 ligases and deubiquitinating enzymes, the enzymes that remove ubiquitin from substrates, with non-lysine activity. Using a multidisciplinary approach involving chemical biology approaches combined with mass spectrometry this project will use a multidisciplinary approach to understand the substrates and cellular functions of these unusual enzymes. 

The project will provide experience with a range of techniques such as chemical biology, cell biology, proteomics and structural biology. Inquisitive and technically minded applicants should find the lab a stimulating environment to conduct research.  

1 De Cesare et al. Biorxivdoihttps://doi.org/10.1101/2020.05.11.087965 

2. Mabbitt et al. Nature Chemical Biology 2020, 16 (11), 1227. 

3Pao et al., Nature Chemical Biology 2016, 12 (5), 324. 

4Pao et al., Nature 2018, 556 (7701), 381.