Systemic fungal infections represent a significant clinical problem which remain hard to treat and are associated high mortality rates. This problem is being exacerbated by the emergence of resistance to existing anti-fungal drugs as well as reports of new fungal species giving rise to systemic fungal infections in the clinic. The innate immune system provides a first line of defence against fungal pathogens, however the interactions between fungal pathogens and innate immune cells are not fully understood. This project will look at the ability of Candida species to activate innate immune cells such as neutrophils and macrophages. Proteomic approaches will be used to map the changes in immune cells and characterise the intracellular signalling networks activated.