University of Dundee

Structural Biology

EASTBIO: *Closing date 10.04.21*: Machine Learning with Molecular Dynamics to uncover allosteric mechanisms of capping enzymes

Molecular dynamics (MD) has matured into a powerful tool for studying dynamics and function of proteins with atomistic and femtosecond resolutions. Typical MD simulations (~microsecond timescale) produce large trajectories of high-dimensional data. A great challenge is to extract useful information about important protein properties from such large (terra- to petabytes) datasets.

China Scholarship Council PhD programme - Intellectual disability in patients with mutations in O-GlcNAc transferase 

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

China Scholarship Council PhD programme - Structural and Mechanistic Chemical Biology of Degraders Mode of Actions

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

China Scholarship Council PhD programme - Non-lysine Deubiquitination

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

EASTBIO: CD8+ T cells in 4-D: characterisation of protein-protein interaction dynamics during T cell activation: Dr T Ly; Dr D Clarke

Advances in mass spectrometry-based proteomics enables comprehensive, quantitative analysis of protein abundance [1] and protein modification by PTMs like phosphorylation. Analysis of protein-protein interactions in a comprehensive fashion remains challenging. Progress has been made using protein correlation profiling (PCP) [2], which combines separations of native protein complexes with MS detection. However, a drawback to PCP is that direct evidence for protein-protein interaction is lacking.

EASTBIO: Cilia and polarity at the intersection of membranes and proteins

The regulation of polarized trafficking processes in cell polarity is important for the organization of cell membranes into structures such as cilia, an antenna on most cells. Understanding this regulation means integrating dozens of factors and signalling pathways known to be important across the regulatory network. Therefore, it is of critical importance to develop an approach that enables analysis of the comparative effects of each component in the system.

Wellcome 4-Year PhD Programme in Integrated molecular, cellular and translational biology

Recruitment for our Wellcome 4-Year PhD Programme in Integrated molecular, cellular and translational biology is now open.  Greater than 40 different supervisors participate with diverse research areas.  Further information can be found on the programme website.  Students on this programme will carry out three short laboratory placements prior to selection of main PhD project.

Deadline for applications set as 10th January 2020