University of Dundee

Developmental Biology

EASTBIO: *Closing Date 10.04.21* Developing proteomics to look at the regulation of innate lymphoid cells by IL-33

Type 2 innate lymphoid cells (ILC2s) play key roles in mediating type 2 immune responses, however beyond their ability to produce cytokines the function and regulation is still poorly understood.  ILC2s are activated by IL-33 and IL-25, both of which are important in the response to helminth infections.   In this project will look at the changes in ILC2s induced by these cytokines, focusing on functions that would help shape the Th2 immune response.  Previous studies on ILC2s have been limited by the low numbers of ILC2s in the body, however recent advances in proteomics and mass spectromet

EASTBIO: Regulation of mRNA capping in embryonic stem cells

Embryonic stem cells are pluripotent cells derived from early embryos that retain the ability to differentiate into all somatic cells.  Pluripotency is dependent on the expression of key pluripotency regulators.  On receiving signals to differentiate, gene expression profiles are reshaped to repress pluripotency factors and to express the proteins required of the new cell lineage.  Our focus is on understanding how cellular signalling pathways regulate the mRNA cap, a structure added to transcripts which is critical for gene expression.   The student will investigate how cellular signalling

EASTBIO CASE: Analysis of protein targets of small molecule splicing modulators

In human cells, almost every gene contains one or more introns that must be removed to generate mRNA. Alternative splicing refers to removing different combinations of introns, thereby generating multiple mRNAs, coding for proteins with different structures, from a single gene. Alternative splicing can generate different protein isoforms, which vary in function, substrate specificity and/or subcellular localisation.

China Scholarship Council PhD programme - How does ester-linked ubiquitin chains regulate the immune system

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

China Scholarship Council PhD programme - Anti-parasitic drugs: Mechanisms and protein modifications

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

China Scholarship Council PhD programme - Investigating the epigenetic basis of preleukaemic stem and progenitor cells in leukemogenesis

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

China Scholarship Council PhD programme - Regulation of RNA cap is embryonic stem cell differentiation

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

China Scholarship Council PhD programme - Mechanisms of chromosome instability in cancer cells

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

China Scholarship Council PhD programme - Intellectual disability in patients with mutations in O-GlcNAc transferase 

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

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