University of Dundee

Cancer Biology

EASTBIO: The regulation of chromosome replication by DBF4-Dependent Kinase

Defects in DNA replication during the process of cell division can lead to long-term problems, including loss of genome integrity, irreparable DNA damage, cell cycle exit  and senescence. The project will address how genome integrity is ensured during cell division, in particular how chromosomal DNA replication is controlled and coordinated with other cell cycle events. An important regulator of DNA replication is the DBF4-Dependent Kinase (DDK) which controls replication initiation and coordinates it with other cell division events such as sister chromatid cohesion.