Most of our food calories come from cereal grain. The development of cereal plants strongly influences the amount of harvested grain or its yield. Cereal stems elongate when they flower (1). Tall cereals easily fall over, a devastating event for farmers, so controlling cereal height is important for cereal breeders. We recently discovered that jasmonate, a classic plant stress/defense hormone, strongly inhibits both flowering and stem elongation in barley (2), suggesting that the jasmonate pathway may be a good breeding target.
Phosphorylation is a major posttranslational modification whose disruption is linked to multiple human diseases. Our lab has recently found a link between the Parkinson’s associated protein kinase PINK1 and a subset of Rab GTPases. This project will employ state-of-the-art methods to uncover the regulation of Rabs by PINK1 in cells .
The project will lead to training in a wide array of technologies including mass spectrometry and biochemistry. The lab is also linked to the EMBO network and the student will also benefit from training opportunities in Europe during their studies.
Ubiquitination is a posttranslational modification that regulates all aspects of physiology and aberrant ubiquitination has been implicated with numerous diseases. Ubiquitination is typically considered a posttranslational modification of lysine residues but it is emerging that non-lysine ubiquitination is intrinsic to mammalian biology. This project will use a multidisciplinary approach to understand the cellular function of non-lysine ubiquitination.
Recruitment for our Wellcome 4-Year PhD Programme in Integrated molecular, cellular and translational biology is now open. Greater than 40 different supervisors participate with diverse research areas. Further information can be found on the programme website. Students on this programme will carry out three short laboratory placements prior to selection of main PhD project.