University of Dundee

Biochemistry

EASTBIO: *Closing date 10.04.21*: Machine Learning with Molecular Dynamics to uncover allosteric mechanisms of capping enzymes

Molecular dynamics (MD) has matured into a powerful tool for studying dynamics and function of proteins with atomistic and femtosecond resolutions. Typical MD simulations (~microsecond timescale) produce large trajectories of high-dimensional data. A great challenge is to extract useful information about important protein properties from such large (terra- to petabytes) datasets.

EASTBIO: Regulation of mRNA capping in embryonic stem cells

Embryonic stem cells are pluripotent cells derived from early embryos that retain the ability to differentiate into all somatic cells.  Pluripotency is dependent on the expression of key pluripotency regulators.  On receiving signals to differentiate, gene expression profiles are reshaped to repress pluripotency factors and to express the proteins required of the new cell lineage.  Our focus is on understanding how cellular signalling pathways regulate the mRNA cap, a structure added to transcripts which is critical for gene expression.   The student will investigate how cellular signalling

EASTBIO CASE: Analysis of protein targets of small molecule splicing modulators

In human cells, almost every gene contains one or more introns that must be removed to generate mRNA. Alternative splicing refers to removing different combinations of introns, thereby generating multiple mRNAs, coding for proteins with different structures, from a single gene. Alternative splicing can generate different protein isoforms, which vary in function, substrate specificity and/or subcellular localisation.

China Scholarship Council PhD programme - How does ester-linked ubiquitin chains regulate the immune system

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

China Scholarship Council PhD programme - Anti-parasitic drugs: Mechanisms and protein modifications

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

China Scholarship Council PhD programme - Convergence of an aphid and oomycete virulence strategy on a negative regulator of plant immunity

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

China Scholarship Council PhD programme - Characterising the immunomodulatory properties of CDK4/6 inhibitors in T cells

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

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