Dr Sharon Matthews
Matthews SA, et al, 2012. Protein Kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues. Eur J Immunol. 42(5):1316-26.
Navarro MN, et al, Matthews SA and Cantrell DA. 2012. Protein Kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T cells. Biochemical Journal, 442(3):649-59
Konopatskaya O, Matthews SA, et al. 2011. Protein Kinase C mediates platelet secretion and thrombus formation through Protein Kinase D2. Blood, 118(2):416-24
Matthews SA, et al. 2010. Unique functions for Protein Kinase D1 and Protein Kinase D2 in mammalian cells. Biochemical Journal, 432(1):153-163
Matthews S.A. and Cantrell D.A. 2009. New insights into the regulation and function of serine/threonine kinases in T lymphocytes. Immunol Rev. Mar;228(1):241-52
Wood CD, Kelly AP, Matthews SA, Cantrell DA. 2007. PDK1-independent activation of the protein kinase C substrate, protein kinase D. FEBS Lett. 581(18):3494-8.
Liu, P, Scharenberg, AM, Cantrell, DA and Matthews, S.A. 2007. PKD enzymes are dispensable for proliferation, survival & antigen receptor-regulated NFkB activity in vertebrate B-cells. FEBS Lett. 581(7):1377-82
Song, Y., Dayalu, R., Matthews, S.A. and Scharenberg, A.M. 2006. TRPML cation channel regulate the specialized lysosomal compartment of vertebrate B-lymphocytes. Eur. J. Cell Biol. Dec;85(12):1253-64
Matthews, S.A. and Cantrell, DA. 2006. The role of serine/threonine kinases in T-cell activation. Curr Opin Immunol. Jun;18(3):314-20
Matthews SA, et al. 2006. Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes. Mol. Cell. Biol. Feb;26(4):1569-77
Matthews, S.A., Dyalu, R. Thompson, L. and Scharenberg, A.M. 2003. Regulation of PKCnu by the B cell antigen receptor. Journal of Biological Chemistry, 278(11):9086-91
Nadler, M.J.S., Matthews, S.A., Turner, H. and Kinet, J.P. 2000. Signal transduction by the high-affinity IgE receptor FceRI. Advances in Immunology, 76: 325-355
Matthews, S.A., T. Iglesias, E. Rozengurt and D. Cantrell. 2000. Spatial and temporal regulation of Protein Kinase D. EMBO Journal, 19(12): 2935-2945
Matthews, S.A., E. Rozengurt, and D. Cantrell. 2000. Protein Kinase D: a selective target for antigen receptors and a downstream target for PKC in lymphocytes. J. of Exp. Med.,191(12): 2075-2082
Matthews, S.A., E. Rozengurt, and D. Cantrell. 1999. Characterization of S916 as an in vivo autophosphorylation site for PKD/PKCµ. J. of Biological Chemistry, 274(37): 26543-26549
Matthews, S.A., T. Iglesias, D. Cantrell, and E. Rozengurt. 1999. Dynamic redistribution of PKD revealed by a GFP-PKD fusion protein. FEBS Letters, 457(3): 515-521
Iglesias, T., S. Matthews, and E. Rozengurt. 1998. Dissimilar phorbol ester binding properties of the individual cys-rich motifs of Protein Kinase D. FEBS Letters, 437(1-2): 19-23
Matthews, S.A., G. R. Pettit, and E. Rozengurt. 1997. Bryostatin 1 induces biphasic activation of Protein Kinase D in intact cells. Journal of Biological Chemistry, 272(32): 20245-2025
As a researcher it is my job to discover new things about biological systems. As a teacher my job is to support and encourage all of our students to take their knowledge and understanding and apply it so that they can make new discoveries for themselves. There is no other job that provides the same kind of satisfaction when our students reach beyond their own expectations!
I contribute to a range of undergraduate modules within degrees spanning all years but have a specialist focus in areas related to biochemistry, cell signalling and immunology. This involves the delivery and assessment of lectures, lab-based practical classes and workshops to Biological and Biomedical Sciences students and Medical students, as well as supervision of undergraduate research projects. My other roles within the School include acting as an Advisor of Studies, serving as School Lead for engagement with Tayside area school teachers, as well as contributing to various Summer Schools.
Modules I contribute teaching to include
- BS11003 Laboratory and Research Skills 1A
- BS11004 Laboratory and Research Skills 1B
- BS21002 The Gene and the Cell
- BS21003 Laboratory and Research Skills 2A
- BS22001* Biomedical Sciences
- BS22002 Biological Sciences
- BS22003 Laboratory and Research Skills 2C
- BS31020 Experimental Cell Culture
- BS32009 Immunology
- BS32028 Molecular Pharmacology
- BS41004 Research Project Supervisor: Biological Sciences
- BS41007 Research Project Supervisor: Biomedical Sciences
- BS42006 Advanced Immunology
- MBChB Immunology, Year 1-3
- MRes Masters in Cancer Biology
- MSci* Integrated Masters in Science
* Module Manager/Deputy Manager
D'Arcy Thompson Unit Divisional Representative for the Division of Cell Signalling and Immunology.
I grew up in Cheltenham (home of the famous Gold Cup horse race!) and studied Medical Sciences at the University of Birmingham. During my degree I carried out a research project on how the enzyme PKCδ was regulated and this led onto a general interest in signal transduction and a PhD at what was then known as the Imperial Cancer Research Fund laboratories (now part of the Francis Crick Institute) in London. After post-doctoral work in the USA I moved to Dundee to work with Prof. Doreen Cantrell on signal transduction in lymphocytes, which is where my interest in understanding the regulation and function of the Immune System was first sparked.
I became a lecturer at the University of Dundee in 2007, initially working in research full-time, and in 2015 I took up a full-time teaching position in the School of Life Sciences where I greatly enjoying using my research skills and knowledge in my various teaching activities.