Dr. Mahima Swamy
Dr. Mahima Swamy is a Wellcome Trust and Royal Society Sir Henry Dale Fellow and Programme Leader in the MRC Protein Phosphorylation and Ubiquitylation Unit, and an associate Principal Investigator of the division of Cell Signalling and Immunology. Her research aims to study the function and regulation of intraepithelial lymphocytes. These are a class of poorly characterised innate-like T cells that reside in the intestinal epithelium, and are central to controlling infection, stress or transformation of the gut epithelium. Understanding the roles of intraepithelial lymphocytes will lead to better understanding of diseases such as inflammatory bowel disorders, infections and cancer.
Chen Y, Vandereyken M, Newton I, Moraga Gonzalez I, Nathke I, Swamy M. 2019. Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22. PLoS Biology. 17(11):1-23. https://doi.org/10.1371/journal.pbio.3000540
Grzes, KM, Swamy, M, Hukelmann, JL, Emslie, E, Sinclair, LV & Cantrell, DA 2017, 'Control of amino-acid transport coordinates metabolic reprogramming in T cell malignancy' Leukemia, vol. 31, pp. 2771-2779. https://doi.org/10.1038/leu.2017.160
Swamy, M, Beck-Garcia, K, Beck-Garcia, E, Hartl, FA, Morath, A, Yousefi, OS, Dopfer, EP, Molnár, E, Schulze, AK, Blanco, R, Borroto, A, Martín-Blanco, N, Alarcon, B, Höfer, T, Minguet, S & Schamel, WWA 2016, 'A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation' Immunity, vol. 44, no. 5, pp. 1091-1101. https://doi.org/10.1016/j.immuni.2016.04.011
Swamy, M, Pathak, S, Grzes, KM, Damerow, S, Sinclair, LV, van Aalten, DMF & Cantrell, DA 2016, 'Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy' Nature Immunology, vol. 17, no. 6, pp. 712-720. https://doi.org/10.1038/ni.3439