Professor Kate Storey FRSE FMedSci
Neural differentiation in embryos and embryonic stem cells
Position:
Professor of Neural Development and Head of the Division of Cell and Developmental Biology
Affiliation:
Address:
School of Life Sciences, University of Dundee, Dundee
Full Telephone:
+44 (0) 1382 385691, int ext 85691
Email:
Website:
Research
We wish to understand how neural cells arise and how their proliferation and differentiation are controlled. Our work focuses on the developing spinal cord and insights from these studies inform our investigation of these processes in embryonic stem cell derived neural tissue and in maturing spinal cord progenitors, which become adult neural stem cells. We address these questions using cell specific gain and loss of gene function approaches as well as genome-wide analyses and real-time imaging techniques. The overall aim of our work is to identify the gene regulatory mechanisms that control neural differentiation, with a long-term goal to inform strategies for therapeutic treatment of neural injury and disease.
Teaching
Contributes lectures to:
Human Embryology and Morphology – year 4
Stem Cells in Development and Disease – year 4
Cell & Developmental Biology – year 3
and supervision for:
Honours student projects – x2 10-week projects
Graduate student seminars/rotation projects – year 1
Publications
Mastromina I, Verrier L, Clara Silva J, Storey K.G, Dale J.K. (2018) MYC activity is required for maintenance of the Neuromesodermal Progenitor signalling network and for correct timing of segmentation clock gene oscillations in mouse. Development. 145:1-14.
d.o.i./10.1242/dev.161091
PMCID 6078331
PMID 30061166
Verrier, L., Davidson, L., Gierlinski, M., Dady, A., and Storey, K.G. (2018) Neural differentiation, selection and transcriptomic profiling of human neuromesodermal progenitors-like cells in vitro. Development. 145(11)
d.o.i./10.1242/dev.166215
PMCID 6124542
PMID 29899136
Kasioulis, I., Storey, K.G. (2018) Cell biological mechanisms regulating chick neurogenesis. International Journal of Developmental Biology. 62(1/2/3): 167-175.
d.o.i 10.1387/ijdb.170268ks
PMID 29616725
Kasioulis, I., Das, R. M. and Storey, K.G. (2017) Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination. eLife.
d.o.i 10.7554/eLife.26215
PMCID 5653239
PMID 29058679
Rodrigo Albors, A. and Storey, K.G. (2016) Mapping body-building potential. eLife. 5, e14830
d.o.i 10.7554/eLife.14830
PMCID 4798963
PMID 26949247
Verrier, L. Davidson, L. Gierliński, M. Storey, K.G. (2016) Generation, selection and transcriptomic profiling of human neuromesodermal and spinal cord progenitors in vitro.
doi: 10.1101/182279
Rodrigo Albors, A, Halley, P.A. Storey, K.G. (2016) Fate mapping caudal lateral epiblast reveals continuous contribution to neural and mesodermal lineages and the origin of secondary neural tube
doi: 10.1101/045872
Henrique, D., Abranches, E., Verrier, L. and Storey, K.G. (2015) Neuromesodermal progenitors and the making of the spinal cord. Development. 142, 2864-2875
d.o.i 10.1242/dev.119768
PMCID 4958456
PMID 26329597
Olivera-Martinez, I., Schurch, N., Li, R. A., Song, J., Halley, P. A., Das, R. M., Burt, D. W., Barton, G. J. and Storey, K.G. (2014) Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo. Development. 141, 3266-3276
d.o.i 10.1242/dev.112623
PMCID 4197544
PMID 25063452
Kalcheim, C. and Storey, K.G (2014) Neural-mesodermal progenitor interactions in pattern formation: an introduction to the collection. F1000Research. 3, 275
d.o.i 10.12688/f1000research.5657.1
PMCID 4288398
PMID 25580236
Das, R. M. and Storey, K.G. (2014) Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis. Science. 343, 200-204
d.o.i 10.1126/science.1247521
PMCID 4066580
PMID 24408437
Schurch, N.J., Cole, C., Sherstnev, A., Song, J., Duc, C., Storey, K.G., McLean, W.H., Brown, S.J., Simpson, G..G and Barton, G.J. (2014) Improved annotation of 3' untranslated regions and complex loci by combination of strand -specific direct RNA sequencing, RNA-Seq and EST's. PloS one. 9, e94270.
d.o.i 10.1371/journal.pone.0094270
PMCID 3983147
PMID 24722185
Patel, N. S., Rhinn, M., Semprich, C. I., Halley, P. A., Dolle, P., Bickmore, W. A. and Storey, K.G. (2013) FGF signalling regulates chromatin organisation during neural differentiation via mechanisms that can be uncoupled from transcription. PLoS genetics. 9, e1003614
d.o.i 10.1371/journal.pgen.1003614
PMCID 3715432
PMID 23874217
Olivera-Martinez, I., Harada, H., Halley, P. A. and Storey, K.G. (2012) Loss of FGF-dependent mesoderm identity and rise of endogenous retinoid signalling determine cessation of body axis elongation. PLoS biology. 10, e1001415
d.o.i 10.1371/journal.pbio.1001415
PMCID 3484059
PMID 23118616
Das, R. M. and Storey, K.G. (2012) Mitotic spindle orientation can direct cell fate and bias Notch activity in chick neural tube. EMBO reports. 13, 448-454
d.o.i 10.1038/embor.2012.42
PMCID 3343353
PMID 22491029
Stavridis, M. P., Collins, B. J., and Storey, K.G. (2010). Retinoic acid orchestrates fibroblast growth factor signalling to drive embryonic stem cell differentiation. Development 137(6): 881-890.
doi/10.1242/dev.043117
PMCID 2834455
PMID 20179094