University of Dundee

Latest News for 08/2020

August 2020

  • Professor Dario Alessi and Professor Kei Sakamoto
    03 Aug 2020

    The three-year alliance will allow knowledge, skills and technology sharing, as well as two joint postdoctoral positions, in order to accelerate discoveries on molecular metabolic signalling in control of glucose homeostasis We are proud to announce the launch of an International Research Alliance between the Medical Research Council Phosphorylation and Ubiquitylation Unit (MRC PPU), at the University of Dundee, and the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), at the University of Copenhagen.

July 2020

  • Dr Gopal Sapkota
    15 Jul 2020

    University of Dundee researchers have demonstrated a new method of destroying an ‘undruggable’ protein known to play a role in cancer, raising the possibility of a new therapeutic approach to the disease. Mutations of the K-Ras protein have long been known to cause many cancers, including lung, colorectal, and pancreatic cancers, but despite decades of work by researchers across the world, an inhibitor for this protein has proven elusive. As a result, scientists have increasingly looked to novel ways of targeting K-Ras.

July 2019

  • Gopal Sapkota
    31 Jul 2019

    Researchers in the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) have solved one of the mysteries of cell division, a discovery which may shed light on cancer development and one day help develop new drugs to treat the disease.

November 2018

  • “Allertek” team Luke Fulcher, Lambert Montava Garriga, Maria Zachari and Marianna Longo
    06 Nov 2018

    PhD students from the MRC PPU took part in the Biotechnology YES 2018 entrepreneurial competition last week. Luke Fulcher (Sapkota lab), Lambert Montava Garriga (Ganley lab), Maria Zachari (Ganley lab) and Marianna Longo (Ganley lab) formed the team “AllerTek” which sought to combat the presence of food allergens in meals.  The biotechnology YES competition allows PhD students from across the UK to compete against each other with their ideas in a “dragons den” style pitch to secure theoretical funding for their innovation.

March 2018

July 2017

  • 03 Jul 2017

    Research by Rosalia Fernandez-Alonso, a post-doctoral investigator in Dr. Greg Findlay’s lab in the MRC-PPU, has been published in and featured on the cover of the July edition of the journal EMBO Reports. The paper identifies a new type of molecular switch involving BET bromodomain proteins, which enables embryonic stem (ES) cells to differentiate into mesendoderm, an important precursor cell that gives rise to tissues and organs such as pancreas, liver, heart and blood.

May 2017

November 2013

October 2013

  • Lina Herhaus
    01 Oct 2013

    The TGFβ signalling pathway controls plethora of cellular functions during embryogenesis and in adult tissues. Consequently abnormal TGFβ signalling is associated with multiple human diseases such as fibrosis, immune disorders and cancer. TGFβ signalling is initiated upon ligand binding to a pair of receptor serine/threonine protein kinases on the cell surface. This triggers the phosphorylation of SMAD2/3 leading to the assembly and nuclear translocation of active SMAD2/3/4 transcriptional complex, which, together with other co-factors, drives the transcription of hundreds of target genes.