University of Dundee

Latest News for 09/2020

June 2020

  • Michaela Omekova
    04 Jun 2020

    The van Aalten lab has been awarded ScotPEN Wellcome Engagement Award to run an innovative project focused on the role of science, lifestyle and one’s social circle in managing neurodegenerative diseases (NDs). The Care to Share project aims to equip participants with practical strategies and networks important in dealing with NDs. The Care to Share project will utilise games to:

April 2020

  • Model for the full-length human OGT
    28 Apr 2020

    Researchers in the School have discovered a new neurodevelopmental disease caused by genetic mutations and helped explain why patients with these mutations suffer this condition. Around 1% of the global population are affected by intellectual disability, a condition characterised by significant limitations in both intellectual function and in adaptive behaviour. It was known that a molecule called GlcNAc was found on proteins related to intellectual disability, but its exact role in this disease remained unclear.

November 2019

  • from left to right: Vladimir Borodkin, Andrii Gorelik, Daan van Aalten, Andrew Ferenbach, Sergio Galan Bartual
    07 Nov 2019

    A University of Dundee discovery has the potential to help scientists better understand neurological diseases such as Alzheimer’s and Parkinson’s. Researchers, led by Professor Daan van Aalten in the School, have developed a new way to tag proteins in human cells with a small sugar molecule called O-GlcNAc. There are over 20,000 proteins in every human cell and approximately 20% of these contain O-GlcNAc. The exact role played by O-GlcNAc remains a mystery but the molecule is found on proteins related to Alzheimer’s, Parkinson’s, motor neurone disease and intellectual disability.

October 2018

  • 11 Oct 2018

    Three of our undergraduate students were recognised in the Undergraduate Awards 2018. Emma Sands, Emily Scott and Daniel Squair were Highly Commended in the Life Sciences category. This means that they were in the top 10% for their category and this included entrants from students across the world! The awards aim to celebrate top undergraduate coursework and foster interdisciplinary collaboration between students and recent graduates worldwide. Our students submitted work based on their fourth year honours project.

April 2018

  • Satpal Virdee and Kuan-Chuan Pao
    12 Apr 2018

    Dr Virdee and colleagues in the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) have discovered a novel class of E3 ligase. The E3 ligase, MYCBP2, operates in a unique way, selectively transferring ubiquitin to non-lysine amino acids with selectivity for threonine. The ubiquitin is linked to the threonine amino acid via a chemically distinct ester linkage thereby uncovering an unanticipated area of cellular biology. The findings are published in Nature.

  • left-to-right, Dr Mehmet Gundogdu, Professor Daan van Aalten and Dr Ulrich Zachariae
    02 Apr 2018

    Scientists in the School have identified the effects of a mutation that gives rise to a form of Intellectual Disability. Intellectual Disability is a type of developmental brain disorder in young patients which to date remains poorly understood and is incurable. Researchers focussed on mutations in the OGT gene, which plays a critical role in protecting brain cells against stress. In patients harbouring OGT mutations, this protective effect is lost.

November 2017

  • Vice President Hu, Jianzhong presented Professor van Aalten with the Certificate of Appointment and the medal that resembles the Hospital.
    01 Nov 2017

    The University of Dundee has formed a new link with China, with Professor Daan van Aalten from the School of Life Sciences being appointed a guest professor at Xiangya Hospital at Central South University in Changsha, China.   Professor van Aalten is a Wellcome Trust Investigator in the Division of Gene Regulation and Expression in the School of Life Sciences. He is one of the world’s leading authorities on the role of the enzyme O-GlcNAc transferase in neurodevelopmental and neurodegenerative diseases.  

October 2017

October 2012

  • 29 Oct 2012

    Researchers at the University of Dundee have uncovered the mechanism of an important human enzyme that plays a role in the development of debilitating diseases including cancer, dementia and diabetes. Professor Daan van Aalten and his team at the University’s College of Life Sciences have been studying how proteins in the cell are regulated by an unusual chemical modification called O-GlcNAc.

February 2011

  • 24 Feb 2011

    Professor Daan van Aalten, of the College of Life Sciences, Division of Molecular Microbiology has been named the joint recipient of the Royal Society of Chemistry’s Dextra Laboratories Carbohydrate Award along with Stuart Haslam from Imperial College. The award, sponsored by Dextra, consists of a silver medal and a cash prize and the recipient is invited to give a lecture at a Royal Society of Chemistry meeting to be held in Liverpool this Autumn (15-16 Sept 2011).

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