Latest News for 04/2019
24 Sep 2018
University of Dundee scientists have been awarded Biotechnology and Biological Sciences Research Council (BBSRC) grants totalling more than £1 million to fund their research into cancer and diabetes.
09 Oct 2017
All living cells make proteins to carry out nearly all the jobs that keep them alive, including the enzymes that speed up chemical reactions and molecular pumps that move molecules from one place to another. All this constant activity is what we call the cell's metabolism. Often scientists seek some kind of Achilles heel in that metabolism to achieve therapeutic intervention.
16 Jun 2017
Why do dogs have puppies, cats have kittens, and we have children with similar characteristics to ourselves? Because information is passed down through the genes, a library of instruction manuals on how to build all living things. Genes are made of the famous double-helical DNA molecule, that encodes information (the instructions) in its structure, in the order of the pieces (the "bases", of which there are four types) that make it up. RNA is similar, yet more dynamic, a worker rather than just a library. This is the basis of the science of genetics.
06 Mar 2017
Professor David Lilley most recent research findings have been published in Nature Chemical Biology today. The paper describes the crystal structure of a new ribozyme (called TS). Ribozymes are RNA molecules that act like enzymes to accelerate chemical reactions. The great majority of enzymes are made of proteins, but a small sub-set are made of RNA (a close chemical cousin of the familiar DNA).
11 Nov 2016
Last month Professor David Lilley from the School of Life Sciences was selected to chair a session at the prestigious Solvay Conference in Brussels. The Solvay Conferences began in 1911 and take place every three years in physics or chemistry. The event is invitation-only and attended by around 50 scientists who are the world leaders in the area of the meeting. The 1911 Solvay Conference in Physics was the first international conference in physics ever to be organised.
19 Sep 2016
Nanotechnology is engineering at an unimaginably small scale, that of individual molecules. Nature has led the way with this, constructing complex structures and functioning machines inside living cells, and scientists are taking a lead from this to engineer molecular-scale objects using natural molecules as building blocks. These could have a variety of potential functions, the most promising of which is the precise, targeted delivery of drug molecules. This is perhaps the real-life equivalent of the old science-fiction movie Fantastic Voyage (1966), or a step in that direction.
09 May 2016
Professor David Lilley, from the University of Dundee, is the Royal Society of Chemistry Khorana Prize winner for 2016. The Khorana Prize recognises outstanding achievement award for research at the chemistry and life science interface. Professor Lilley receives £5000, a medal and a certificate.
18 Dec 2015
An enzyme crucial to the process of DNA repair in our cells has been mapped in atomic detail by researchers at the University of Dundee, the UK’s top-rated University for Biological Sciences. DNA repair plays a key role in human diseases such as cancer. Researchers say that revealing the 3D molecular structure of a key enzyme involved in this process could be an important step towards developing future drugs.
03 Feb 2015
David Lilley has been awarded the RNA Society’s 2015 Lifetime Service Award Professor Lilley is Chair of Molecular Biology and Director of the CR-UK Nucleic Acid Structure Research Group at the University of Dundee. He has spent over 40 years studying the structure and physical biochemical properties of nucleic acids and proteins, including chromatin complexes, DNA & RNA junctions and cruciforms, multiple ribozyme motifs, and numerous nucleic acid modifications.
31 Oct 2014
Scientists at the University of Dundee have discovered a hidden `code’ that tells our key genetic molecules how to structure themselves, thereby allowing them to carry out their work. In a research paper published in the journal Nature Communications, Professor David Lilley and colleagues describe how a crucial part of RNA called the `kink-turn’ operates.