Articles:
1. Bustos, F. et al. Activity-based probe profiling of RNF12 E3 ubiquitin ligase function in Tonne-Kalscheuer syndrome. Life Sci Alliance, 5, e202101248 (2022).
2. Spear, L. A. et al. Selective Inhibition of Cysteine-Dependent Enzymes by Bioorthogonal Tethering. J Mol Biol 434, 167524 (2022).
3. Cesare, V. D. et al. Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases. Proc National Acad Sci 118, e2006947118 (2021).
Highlighted in: Kessler, B. M. DUB esterase activity further decodes ubiquitin's enigma. Proc National Acad Sci 118, e2026389118 (2021).
4. Mabbitt, P. D. et al. Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity. Nat Chem Biol 16, 1227-1236 (2020).
Highlighted in: Faculty Opinions
European Synchrotron Radiation Facility (ESRF) Annual Highlights 2020
Lorenz, S. & Rittinger, K. Advanced rules of relays. Nat Chem Biol 16, 1158-1159 (2020).
5. Mathur, S., Fletcher, A. J., Branigan, E., Hay, R. T. & Virdee, S. Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases. Cell Chem Biol 27, 74-82.e6 (2019).
6. Pao, K.-C. et al. Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. Nature 556, 381-385 (2018).
Highlighted in: Faculty Opinions
European Synchrotron Radiation Facility (ESRF) Spotlight on Science
European Synchrotron Radiation Facility (ESRF) Annual Highlights 2018

7. Kwasna, D. et al. Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability. Mol Cell 70, 150-164.e6 (2018).
8. Pao, K.-C., Stanley, M., Han, C., Lai, Y.-C., Murphy, P., Balk, P., Wood, N., Corti, O., Corvol, J.-C., Muqit, M. M. K., & Virdee, S. Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation. (2016) Nat Chem Biol 12, 324-331.
9. Han, C., Pao, K-C., Kazlauskaite, A., Muqit, M. M. K. & Virdee, S. A Versatile Strategy for the Semisynthetic Production of Ser65 Phosphorylated Ubiquitin and its Biochemical and Structural Characterization. (2015) Chembiochem, 16, 1574-1579.
10. Stanley, M., Han, C., Knebel, A., Murphy, P., Shpiro, N. & Virdee, S. Orthogonal Thiol Functionalization at a Single Atomic Center for Profiling Transthiolation Activity of E1 Activating Enzymes. (2015) ACS Chem Biol 10, 1542-1554.
11. Bett, J. S., Ritorto, M. S., Ewan, R., Jaffray, E. G., Virdee, S., Chin, J. W., Knebel, A., Kurz, T., Trost, M., Tatham, M. H. & Hay, R. T. (2015) Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide- linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers. Biochem. J. 466, 489-498.
Highlighted in: Faculty Opinions
12. Ritorto, M. S., Ewan, R., Perez-Oliva, A. B., Knebel, A., Buhrlage, S. J., Wightman, M., Kelly, S. M., Wood, N. T., Virdee, S., Gray, N. S., Morrice, N. A., Alessi, D. R., & Trost, M. Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. (2014) Nat. Commun. 5, 4763.
13. Licchesi, J. D. F., Mieszczanek, J., Mevissen, T. E. T., Rutherford, T. R., Akutsu, M., Virdee, S., Oualid, F., E., Chin, J. W., Ovaa, H., Bienz, M. & Komander, D. An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains. (2012) Nat. Struct. Mol. Biol. 19, 62-71.
14. Virdee, S., Kapadnis, P., Elliot, T., Lang, K., Madrzak, J., Nguyen, D.P., Riechmann, L. & Chin, J.W. (2011) Traceless and site-specific ubiquitination of recombinant proteins. J. Am. Chem. Soc. 133, 10708-10711.
Highlighted in: Faculty Opinions
Chemical and Engineering News 2010
Chemical and Engineering Chemical Year in Review 2010
Angewandte Chemie.
15. Akutsu, M., Ye, Y., Virdee, S., Chin, J. W. & Komander, D. Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains. (2011) Proc. Nat.l Acad. Sci. U S A 108, 2228-2233.