Email: y.yin@dundee.ac.uk

Yili joined the lab in October 2007 as a post doctorial research fellow funded by CRUK. She is currently trying to identify new factors involved in sumolytion-dependent transcription repression by screening siRNA and also investigating the role of SUMOlytion in stress responses in human cells.

Yili qualified as a medical doctor in China and attained Consultant Physician status working as a Gerontologist in Beijing. She was awarded a PhD in 2004 for research on ‘The N-terminal sequences in EBV-EBNA1 and p53 regulate protein synthesis and proteasomal degradation’ in School of Life Sciences, Dundee. She then moved on to the post of post doctoral researcher in Professor Tickle’s lab exploring the mechanism of Sonic Hedgehog (shh) pathway using a chick mutant as a model system. This work has identified a new component of shh, talpid3 and investigated its functions.

Refs

Yin Y, Seifert A, Chua JS, Maure J-F, Golebiowski F, Hay RT. (2012) SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage Genes and Development 26:1196-1208

Golebiowski F, Matic I, Tatham MH, Cole C, Yin Y, Nakamura A, Cox J, Barton GJ, Mann M, Hay RT. System-wide changes to SUMO modifications in response to heat shock. Sci Signal. 2009 May 26;2(72):ra24.PMID: 19471022

Apcher S, Komarova A, Daskalogianni C, Yin Y, Malbert-Colas L, Fåhraeus R. mRNA translation regulation by the Gly-Ala repeat of Epstein-Barr virus nuclear antigen 1. J Virol. 2008 Nov 19.

Towers M, Mahood R, Yin Y, Tickle C. Integration of growth and specification in chick wing digit-patterning. Nature. 2008 Apr 17; 452(7189):882-6.

Davey MG, Paton IR, Yin Y, Schmidt M, Bangs FK, Morrice DR, Smith TG, Buxton P, Stamataki D, Tanaka M, Münsterberg AE, Briscoe J, Tickle C, Burt DW. The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling. Genes Dev. 2006 May 15; 20(10):1365-77.

Yin Y, Manoury B, Fåhraeus R. Self-inhibition of synthesis and antigen presentation by Epstein-Barr virus-encoded EBNA1. Science. 2003 Sep 5; 301(5638):1371-4.

Yin Y, Stephen CW, Luciani MG, Fåhraeus R. p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products. Nat Cell Biol. 2002 Jun; 4(6):462-7.