Email: l.z.shen@dundee.ac.uk

Linnan joined the Hay lab as a postdoctoral researcher in 2001. His project mainly focused on the structural characterization of SUMO specific proteases (SENPs).

He obtained his PhD in biochemistry at East China University of Science and Technology, studying high density cell culture of E.coli for production of recombinant FGF under the supervision of Professor Juntang Yu and Professor Dongzi Wei.

Refs

The SUMO protease SENP6 is a direct regulator of PML nuclear bodies. Hattersley N, Shen L, Jaffray EG, Hay RT. Mol Biol Cell. 2011 Jan 1;22(1):78-90. doi: 10.1091/mbc.E10-06-0504. Epub 2010 Dec 9.
PMID: 21148299

Shen LN, Geoffroy MC, Jaffray EG, Hay RT. Characterization of SENP7, a SUMO-2/3-specific isopeptidase. Biochem J. 2009 Jun 26;421(2):223-30.PMID: 19392659

Tatham MH, Geoffroy MC, Shen L, Plechanovova A, Hattersley N, Jaffray EG, Palvimo JJ, Hay RT. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PMLdegradation. Nat Cell Biol. 2008 May; 10(5):538-46.

Shen L, Tatham MH, Dong C, Zagórska A, Naismith JH, Hay RT. SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol. 2006 Dec; 13(12):1069-77.

Shen LN, Dong C, Liu H, Naismith JH, Hay RT. The structure of SENP1-SUMO-2 complex suggests a structural basis for
discrimination between SUMO paralogues during processing. Biochem J. 2006 Jul 15; 397(2):279-88.

Shen LN, Liu H, Dong C, Xirodimas D, Naismith JH, Hay RT. Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J. 2005 Apr 6; 24(7):1341-51.

Mendoza HM, Shen LN, Botting C, Lewis A, Chen J, Ink B, Hay RT. NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem. 2003 Jul 11; 278(28):25637-43.