I am investigating the development and anatomy of the adult mouse spinal cord central canal. I use a combination of high-resolution imaging, lineage tracing and ex-vivo slice culture approaches. My work is funded by an Anatomical Society studentship.
My project addresses the regulation of differentiation by signalling pathways and transcription factors in the elongating body axis. I am jointly supervised by Kim Dale and Kate Storey. My research is supported by Cancer Research UK.
My work addresses the mechanisms downstream of differentiation signalling pathways that direct higher order chromatin organization. I use a combination of mouse embryo culture and small molecule approaches together with Western blotting, FISH and immunocytochemistry. I am supported by a BBSRC DTA studentship.
Adriana Amorin Torres
I am investigating the role and regulation of the polycomb repressor complex associated protein Jarid2 during early embryonic development, using chick and mouse model systems. My research is supported by a CAPES studentship for Brazilian students.
Dr Alwyn Dady
I am developing imaging assays and cell lines with which to investigate human neuroepithelial cell behaviour. My work is supported by the Wellcome Trust.
Dr Ioannis Kasioulis
I am investigating aspects of the molecular mechanisms underlying apical abscission, focusing on the role and regulation of microtubules in this process. I use live cell imaging approaches as well as high-resolution microscopy. The Wellcome Trust supports my work.
Dr Nadège Poncet
I am researching neural developmental defects in mouse embryos lacking Slc7a5 (LAT1), which transports thyroid hormone or large neutral amino acids. I use mouse genetics, immunocytochemistry, transcriptomics and imaging approaches. I am supported by a grant from the Wellcome Trust to Dr Peter Taylor, collaborating with Kate Storey to investigate the developmental phenotype of this mouse mutant.
Dr Aida Rodrigo Albors
I am using single-cell transcriptomics and high-resolution microscopy to characterise ependymal cells of the mouse spinal cord. These cells are morphologically and molecularly heterogeneous and some are thought to retain neural stem cell potential throughout life. I aim to make sense of ependymal cell heterogeneity and perhaps find out the identity of the elusive spinal cord neural stem cell. My project is supported by a Marie Skłodowska-Curie post-doctoral fellowship.
Mrs Pam Halley
I am involved in several research projects in the lab and take primary roles in running the mouse colonies, supporting tissue preparation for imaging approaches and pioneering molecular biology approaches.
Mrs Gail Singer
I use a range of technical approaches to quantify transcripts and proteins at single cell resolution in the spinal cord central canal. My work is supported by the charity Wings for Life.