Postdoctoral Scientists

Positions Available

(New - August 2021!)

We have openings available immediately for postdoctoral scientists in the group to boost our efforts in targeted protein degradation and PROTAC design and drug discovery. The posts will be based under Dundee's new Centre for Targeted Protein Degradation (CeTPD).

 

SLSC0910: Computational Drug Design and Molecular Modelling Scientist (PROTAC drug discovery)

We are seeking a highly motivated computational chemist to join a multi-disciplinary drug discovery team based in a new Centre for Targeted Protein Degradation (CeTPD) within Dundee’s School of Life Sciences. The team is engaged in an exciting collaboration on proteolysis-targeting chimeras (PROTAC), between the laboratories of Professor Alessio Ciulli and Boehringer Ingelheim. Our mission is to discover novel small-molecule degraders to treat cancers with serious unmet medical needs. There is significant scope for the successful candidate to develop how computational approaches can augment our world leading capabilities in biophysics and structure driven PROTAC design.

The opportunity will suit candidates with experience in computational chemistry and/or molecular modelling who are interested in applying their knowledge to PROTAC drug discovery. The post holder will be expected to work independently while interacting closely with medicinal chemists and structural biologists within the Dundee Team. There will also be scope and opportunities to interact closely with other computational chemists within the wider CeTPD at Dundee, and at Boehringer Ingelheim.

Candidate Requirements:

  • Ph.D. or Masters with relevant experience in industry in computational chemistry
  • Experience in applying a range of computational tools to improve ligand:protein binding
  • A keen interest to learn new techniques and to grow your own computational drug discovery repertoire.
  • Strong interpersonal, communication and presentation skills
  • Excellent data handling skills

The post is available to start immediately, with funding available until 31 December 2023 in the first instance. The appointment will be made at Grade 7. 

More information on the position and how to apply can be found here

Closing date: Friday, 3 September 2021

 

SLSC0911: Scientist, Medicinal Chemistry / Organic Chemistry

We are seeking a highly motivated scientist with research experience in organic chemistry and/or medicinal chemistry to join a multi-disciplinary drug discovery team based in a new Centre for Targeted Protein Degradation (CeTPD) within Dundee’s School of Life Sciences. The team is engaged in an exciting collaboration on proteolysis-targeting chimeras (PROTAC), between the laboratories of Professor Alessio Ciulli and Boehringer Ingelheim. Our mission is to discover novel small-molecule degraders to treat cancers with serious unmet medical needs. The scientist will be expected to boost the drug design and synthesis approaches the team are taking to accelerate translation of research in this field and to develop degrader drug candidates.

The opportunity will suit candidates with experience in organic chemistry and/or medicinal chemistry / chemical biology who are interested in applying their knowledge to PROTAC drug discovery. 

Candidate Requirements:

  • Ph.D. in organic chemistry, medicinal chemistry or a related discipline is required
  • High level of expertise in synthetic organic chemistry and synthetic route design
  • Strong interpersonal, communication and presentation skills
  • A demonstrated ability to problem-solve within a team environment

The post is available to start immediately, with funding available until 31 December 2023 in the first instance. The appointment will be made at Grade 7. 

More information on the position and how to apply can be found here

Closing date: Friday, 3 September 2021

 

SLSC0921: Postdoctoral Research Assistant (Development of Chemical Probes for E3 Ligases)

We are seeking an ambitious and scientifically-creative postdoctoral researcher with experience in medicinal/organic chemistry to join our laboratory, based in a new Centre for Targeted Protein Degradation (CeTPD) within Dundee’s School of Life Sciences. The successful candidate will join a diverse, fast-paced and collaborative team based within the Ciulli group to contribute to multi-disciplinary projects as part of EUbOPEN (https://www.eubopen.org/). EUbOPEN is a multi-partner, highly collaborative consortium recently established and funded for 5 years by the Innovative Medicines Initiative (IMI) to enable and unlock biology in the open.

The scientist will be expected to design, synthesise and optimize small-molecule binding ligands and chemical probes (drug-like inhibitors) that target E3 ligases, enzymes that tag substrate proteins with ubiquitin. The ultimate goal of the project is to qualify high-affinity, selective and cell-active small molecules as tool compounds to investigate the E3 ligase target’s biology, and as starting points for conjugation into bifunctional degrader molecules, also known as proteolysis-targeting chimeras (PROTACs), co-opting novel E3 ligases for targeted protein degradation. This is a unique opportunity to gain experience in world-leading, collaborative and cutting-edge research in one of the hottest area of modern translational chemical biology and drug discovery within an academic setting with an open-science ethos.

Candidate Requirements:

  • A PhD in organic chemistry, medicinal chemistry, chemical biology or a related discipline is required.
  • High level of expertise in synthetic organic chemistry and synthetic route design.
  • Strong interpersonal, communication and presentation skills.
  • A demonstrated ability to problem-solve within a team environment.
  • An open and collaborative approach to science

Preferred skills:

  • Experience with fragment-based and structure-based drug design.
  • Experience with studying and targeting protein-ligand and protein-protein interactions
  • Outstanding academic or industrial track records
  • Exceptional time management, organisational and self-motivational skills

The post is available to start immediately, with funding available until 31 August 2023 in the first instance, which may be extendable dependent on project progress and funding. The appointment will be made at Grade 7. 

More information on the position and how to apply can be found here

Closing date: Monday, 13 September 2021

 

 

We are always looking for talented, self-motivated and creative individuals with interest in targeted protein degradation and protein-protein interactions, and skills and expertise from a wide range of areas: from chemical synthesis and chemical biology, to structural cell biology, fragment-based drug discovery and computational chemistry. There are opportunities to work on a wide range of different projects as part of a multidisciplinary group in the Ciulli lab. Vacancies become available periodically, and these posts will be advertised here and here. However, the timescale for filling these vacancies can be short, so if you are planning a career that involves training and working with us, the best way to guarantee a place in the lab is to secure an independent postdoctoral fellowship. Links to some of the organisations that sponsor fellowships are provided below, but this list is not exhaustive, so it may be worth doing your own research.

Please contact me by email if you intend to apply for your own funding. Sources of funding include:

EU Marie Skłodowska-Curie Actions Individual Fellowships
- Postdoctoral Fellowships from EMBOFEBS, and HFSP
Wellcome Trust Fellowships
- the Royal Society Fellowships and the Newton Trust International Fellowships
SULSA Postdoctoral and Early Career Researcher Exchanges
The Leverhulme Trust

A number of Postdoctoral Scholarships and Sponsorships are also available from the following countries:

UK (The Royal Commission for the Exhibition of 1851)
Germany (DAAD, DFG e.g. Walter Benjamin program and Alexandre Von Humboldt Foundation)
- Switzerland (SNF Postdoc Mobility and Early Postdoc Mobility)
- Denmark (Villum Kann Rasmussen Fonden)
- Finland (Academy of Finland and PostDoc Pool)
- Sweden and Italy (Foundation BLANCEFLOR Boncompagni-Ludovisi)
- Sweded (Swedish Research Council 
Vetenskapsrade)
- Spain (Beatriu de Pinos programme)
- Portugal (FCT - Fundação para a Ciência e a Tecnologia)
- Australia (Australian National Health and Medical Research Council, Endeavour Leadership Program)
- Canada (CIHR and NSERC). The difference is basic science (NSERC) vs translational/medical impact (CIHR), this link will give a clearer picture.
- Japan (JSPS)
- United States (NSF)

A detailed list of funding schemes and opportunities for postdoctoral fellowships can be found here.