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Ciulli Laboratory
School of Life Sciences, University of Dundee
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Alessio Ciulli
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Targeted Protein Degradation: PROTACs
Cullin RING E3 Ubiquitin Ligases
Chromatin-Reader Domains
Fragment-Based Ligand Discovery
Chemical Probes
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October 2021
Our new paper in Nature Chemical Biology reports trivalent PROTACs as a strategy to boost targeted protein degraders mechanism of action
Tag tech provides insight into undruggable diseases
Introducing BromoTAG and AGB1: our new inducible degron system for potent, rapid, selective protein degradation
New openings and website now live for our newly-announced Centre for Targeted Protein Degradation (CeTPD)
Lab contributing to Dundee being ranked top 6 in UK for spinout success
July 2021
Our beginner’s guide to PROTACs and targeted protein degradation is now out in The Biochemist
Successful anti-cancer alliance extended
New pre-print: Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity
June 2021
New preprint: Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay
April 2021
First-of-its-kind centre to lead protein degradation revolution
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