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Ciulli Laboratory

School of Life Sciences, University of Dundee

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    • Targeted Protein Degradation: PROTACs
    • Cullin RING E3 Ubiquitin Ligases
    • Chromatin-Reader Domains
    • Fragment-Based Ligand Discovery
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News

October 2021

  • Our new paper in Nature Chemical Biology reports trivalent PROTACs as a strategy to boost targeted protein degraders mechanism of action
  • Adam & Conner
    Tag tech provides insight into undruggable diseases
  • ToC graphics
    Introducing BromoTAG and AGB1: our new inducible degron system for potent, rapid, selective protein degradation
  • Come join us!
    New openings and website now live for our newly-announced Centre for Targeted Protein Degradation (CeTPD)
  • Dundee's School of Life Sciences
    Lab contributing to Dundee being ranked top 6 in UK for spinout success

July 2021

  • Figure 1. The Journey of a PROTAC. Cartoon depiction of the journey of a PROTAC molecule, starting with entry into the cell and resulting in degradation of a protein target. Once complete, the PROTAC is free to repeat the cycle. *The binary interaction step can occur with either E3 ligase or protein target.
    Our beginner’s guide to PROTACs and targeted protein degradation is now out in The Biochemist
  • AC-BI Team in Jan 2019
    Successful anti-cancer alliance extended
  • ToC graphics
    New pre-print: Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity

June 2021

  • ToC graphics
    New preprint: Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay

April 2021

  • First-of-its-kind centre to lead protein degradation revolution

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Prof Alessio Ciulli
Professor of Chemical and Structural Biology
School of Life Sciences, University of Dundee
Division of Biological Chemistry & Drug Discovery
1 James Lindsay Place
Dundee
DD1 5JJ
United Kingdom

E-mail: a.ciulli@dundee.ac.uk
Tel: +44 (0)1382 386230
Fax: +44 (0)1382 386373

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