Our review on structure, protein-protein interactions and drug discovery targeting Cullin RING E3 Ubiquitin Ligases is now published in the Biochemical Journal

  • Front page
  • Figure 1 Cullin RING E3 ubiquitin ligases
  • Figure 2 Assembly between substrate receptor ‘box’ domains and adaptor subunits
  • Figure 3 Assembly between adaptor subunits and Cullins
  • Figure 5 Crystal structure of Skp1–Cdc4–SCF-I2 complex (PDB code 3MKS)
  • Figure 4 Chemical structures of published small-molecule modulators of CRL activity
  • Figure 6 Crystal structure of the Skp1–TIR1–Probe 8 complex (PDB code 3C6N)
  • Figure 7 Crystal structure of the VHL–ElonginB–ElonginC–Compound 7 complex (PDB code 4W9H)
  • Figure 8 Crystal structure of the Keap1–SRS-59 complex (PDB code 4L7D)
  • Figure 9 Crystal structure of the Keap1–Cpd16 complex (PDB code 4IQK)
  • Figure 10 Crystal structure of the CRBN–DDB1–thalidomide complex (PDB code 4CI1)
  • Figure 11 (top) Structures of CC0651 bound to an allosteric pocket on the E2-conjugating enzyme Cdc34
  • Figure 11 (bottom) Structures of CC0651 bound to an allosteric pocket on the E2-conjugating enzyme Cdc34
  • Figure 12 Crystal structure of the NAE1–UBA3–NEDD8∼MLN4924 complex (PDB code 3GZN)

You can read our paper Open Access here.