Our review on NMR approaches in structure-based lead discovery for targeting multi-protein complexes is now published in Prog. Biophys. Mol. Biol.

  • Figure 5. Different labelling schemes and respective spectra in von Hippel-Lindau protein (pVHL) E3 ubiquitin ligase multi-subunit complex.
  • Figure 1. Representative NMR techniques used for hit generation.
  • Figure 2. Schematic representation of the stepwise approach of SAR by NMR.
  • Figure 3. NMR techniques used to study ligand-bound conformation and protein binding sites identification.
  • Figure 4. Isotopic labelling strategies to aid NMR studies of multi-protein targets.
  • Figure 6. Different protein dynamics and timescales accessible to NMR spectroscopy.

You can read our paper open-access here.