Our paper on the molecular recognition of helical histone tail by PHD finger domains is now published in Biochemical Journal

  • ToC graphics
  • Figure 1. Structural basis of H3 recognition by BAZ2A PHD.
  • Figure 2. ‘Acidic wall’ residue is conserved among PHD fingers that recognize helical H3 tail.
  • Figure 3. CSPs induced by the H3 10-mer peptide on BAZ2A PHD.
  • Figure 4. Characterization of the interaction between H3 N-terminal tail and BAZ2A/B PHD in solution by NMR.
  • Figure 5. Role of the acidic wall residue of BAZ2A/B PHDs in H3 N-terminal tail recognition.
  • Figure 6. MD simulations of helicity of H3 N-terminal tail, WT and mutant.
  • Figure 7. Helical propensity of H3-derived peptides studied by CD.

Well done to Alessio B., Anastasia, Xavi - and Manuel!

Read the full paper open access here.