Our paper characterising VHL inhibitor VH298 as novel chemical probe of the hypoxia signalling pathway is now published in Nature Communications

  • A visual representation of the crystal structure of the VH298 molecule bound to its target VHL
  • PhD students Julianty and Pedro explained their contributions to the work
  • Figure 1: Biophysical and structural characterization of VH298, a new potent VHL inhibitor.
  • Table 1: Structures and summary of biophysical, permeability and lipophilicity results for VHL inhibitors.
  • Figure 3: VHL inhibitors induce HIF-α transcriptional activity in various cell lines.
  • Figure 4: VH298 elicits a HIF-dependent hypoxic response in various cell lines.
  • Figure 2: VH298 induces concentration- and time-dependent on-target specific accumulation of hydroxylated HIF-α in human cell lines.

Read our open access article here.

Access VH298 from the Chemical Probes portal here.