We are excited to share our new review on Proximity-Based Modalities for Biology and Medicine | Just out ASAP in ACS Central Science
Xingui and Alessio delve into various modes of action being pursued, not just PROTACs and molecular glue degraders but also stabilisers, modulators of protein post-translational modifications, cellular localization, and agents for cell therapy. They highlight the opportunities and also the gaps and challenges that the field must address for the emerging proximity-inducing mechanisms beyond PROTACs to mature and unlock translation for biology and medicine.
It is hoped that this Outlook will prove useful and will inspire the next steps in the field.
Read the full article Open Access here
Authors: Xingui Liu, Alessio Ciulli*
Title: Proximity-Based Modalities for Biology and Medicine
Molecular proximity orchestrates biological function, and blocking existing proximities is an established therapeutic strategy. By contrast, strengthening or creating neoproximity with chemistry enables modulation of biological processes with high selectivity and has the potential to substantially expand the target space. A plethora of proximity-based modalities to target proteins via diverse approaches have recently emerged, opening opportunities for biopharmaceutical innovation. This Outlook outlines the diverse mechanisms and molecules based on induced proximity, including protein degraders, blockers, and stabilizers, inducers of protein post-translational modifications, and agents for cell therapy, and discusses opportunities and challenges that the field must address to mature and unlock translation in biology and medicine.