New paper: Structure-guided design of peptides targeting the protein-protein interaction between Cullin-2 and Elongin BC adaptor in Cullin RING E3 ubiquitin ligases

  • ToC: Cul2-based peptides
  • Figure 1. A) N-terminal tail in the Cullin family. B) The CRL2VHL complex.
  • Figure 2 – Biolayer interferometry data of N-terminal Cul2 peptides versus VBC.
  • Table 1 – Results from the BLI experiment with the peptide variants replacing Leu3.
  • Figure 3 – Biophysical characterization of peptide J binding to VBC.
  • Figure 4 – Chemical shift perturbation analysis by NMR spectroscopy.

Congratulations to Teresa.

Read our full paper open access here.