"Mind the Zinc" from Fragment Libraries: Our collaborative paper with Helen Walden's Lab on targeting the E2 Ubiquitin-Conjugating Enzyme Ube2T now published in J. Med. Chem.

  • ToC graphics
  • Figure 1. Biophysical and biochemical characterization of compound 1.
  • Chart 1. Chemical Structures of Compound 1 Analoguesa
  • Scheme 1. Synthesis of Amidines 7, 10, 11, 13, and 14
  • Figure 2. Zinc-mediated Ube2TΔC oligomerization.
  • Figure 3. Confirmation of zinc contamination and binding effect.

Read the full article Open Access here

Check out the post by Derek Lowe in his blog "In The Pipeline" here