Allosteric targeting of the E2 conjugating enzyme Ube2T by fragment screening: our collaborative work with Helen Walden is now published in J. Med. Chem.

  • Allosteric targeting of E2 conjugating enzymes
  • Figure 1. Chemical shift perturbations observed upon addition of 3 mM fragment to 80 μM Ube2T1−154.
  • Figure 2. Crystal structure of EM04 in complex with Ube2T.
  • Figure 3. Fragments inhibit substrate ubiquitination by Ube2T.

Well done to Ester!

Read our article open access here.