University of Dundee

"Priming the NLRP3 inflammasome"

Event Date: 
Wednesday, June 15, 2022 - 13:00 to 14:00
Event Location: 
Sir Kenneth & Lady Noreen Murray Seminar Room CTIR-284
Host: 
Professor Simon Arthur
Event Speaker: 
Dr Jelena Bezbradica Mirkovic
Institution: 
University of Oxford
Event Type: 
Seminar
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Division of Cell Signalling and Immunology & TIG 

 

School of Life Sciences 

 

Hybrid Seminar 

My research goal is to elucidate mechanisms that control the initiation and duration of inflammatory responses in innate immune cells. To accomplish this goal, we study innate sensing and signalling in myeloid cells, such as macrophages, as these cells typically initiate the inflammatory response. Our group investigates how innate cells integrate signals from cytokines (which report on infection or tissue injury) with signals from microbial and tissue-damage sensors to direct the most appropriate effector response. 

The NLRP3 inflammasome is one such critical sensor of cell and tissue homeostasis that becomes activated in response to pathogen- or tissue-derived danger signals. While beneficial during infections and vaccinations, excessive and uncontrolled NLRP3 activity contributes to the development of several inherited diseases such as Cryopyrin-Associated Periodic Syndromes (CAPS), or acquired, non-communicable and lifestyle-related inflammatory diseases, such as Arthritis, Gout, or aging-associated inflammation and functional decline. Hence, we study how the NLRP3 pathway activity is ‘turned on and off’ in healthy individuals to be able to harness this knowledge for future therapeutic interventions allowing control over inflammasome response.