University of Dundee

‘Mining Understudied Kinases for Novel Targets in Squamous Cell Carcinomas’

Event Date: 
Friday, September 17, 2021 - 13:00 to 14:00
Event Location: 
Professor Dario Alessi FRS FRSE FMedSci
Event Speaker: 
Pedro Torres-Ayuso
Laboratory of Cell and Developmental Signaling National Cancer Institute Frederick, Maryland
Event Type: 

Pedro Torres is currently working as a postdoc on kinase biology in Dr. John Brognard’s lab at the National Cancer Institute. He is currently searching for a PI position and we have invited him to give us a seminar to discuss and receive feedback his previous research and future plans. He has done some very original work on characterisation of poorly studied atypical kinases. One of the highlights is work that he has recently undertaken with the TNIK protein kinase that indicates that this is kinases is hyperactivated and a therefore a novel actionable target in lung squamous cell carcinoma. He has developed approaches to identify TNIK-regulated pathways that can be used as biomarkers to identify cancers that are driven by overactivation of the TNIK pathway. In his future work Pedro is keen to investigate how inhibitors of TNIK could be developed, including PROTAC-like compounds. He is also keen to develop pre-clinical cancer models, including patient-derived xenograft and circulating tumour cell-derived explant, to validate novel therapeutic targets and drug combinations in lung and head and neck squamous cell carcinomas. These partnerships have worked in the past to help translate the findings of my research into pre-clinical stages.


This seminar would be interesting for students and postdocs to see how to pitch your research when searching for a PI position.  





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