University of Dundee

‘Tête-à-tête: The p97-UBXD8 complex regulates ER-mitochondrial contact sites’

Event Date: 
Thursday, November 21, 2019 - 12:00
Event Location: 
School of Life Sciences, MSI Small Lecture Theatre
Dr. Yogesh Kulathu
Event Speaker: 
Dr Malavika Raman
Tufts University School of Medicine, Boston
Event Type: 

Malavika (Mali) Raman is originally from Chennai India. She earned her undergraduate degree in Biology and Pharmacy at the Birla Institute of Technology and Science in Rajasthan India. In 2001 she joined the laboratory of Melanie H. Cobb in the Department of Pharmacology at the University of Texas Southwestern Medical Center in Dallas, Texas. Her graduate thesis work involved characterizing TAO kinases, a poorly understood family of MAP3-Kinases that regulated p38 MAPK. She uncovered a role for TAOs in the DNA damage signaling pathway by relaying activation from the ATM kinase to p38 to mediate cell cycle arrest and DNA repair. In 2008 she moved to Harvard Medical School to perform post-doctoral studies in the laboratory of Wade J. Harper in the Department of Cell Biology. In Wade’s lab she performed a genome-wide siRNA screen to identify how DNA damage signaled the ubiquitin-mediated degradation of the DNA licensing factor CDT1. This effort uncovered a role for the nucleotide excision repair machinery, the COP9 signalosome and the p97 AAA-ATPase in mediating CDT1 degradation on chromatin. She subsequently became fascinated with p97 and went on to characterize protein complexes associating with p97 adaptors by mass spectrometry. Her work identified an entirely unappreciated role for p97 and a poorly studied adaptor UBXN10 in regulating the formation of cilia. In 2016, she started her own research group at Tufts University School of Medicine. Her lab is focused on understanding the role of p97 in proteostasis and deciphering how p97 deregulation causes neurodegeneration.