University of Dundee

“The Emerging Roles of the Lysosome in Metabolic Homeostasis”

Event Date: 
Friday, November 22, 2019 - 13:00
Event Location: 
School of Life Sciences, MSI Small Lecture Theatre
Host: 
Professor Dario Alessi FRS FRSE
Event Speaker: 
Dr Monther Abu-Remaileh
Institution: 
Stanford University
Event Type: 
Seminar
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Monther is currently an Assistant Professor of Chemical Engineering and Genetics and Institute Scholar of ChEM-H at Stanford University.  Monther worked for many years in David Sabatini's lab dissecting how the mTOR pathway is activated at the lysosome membrane in response to nutrients such as amino acids.  His biggest technological advance was to develop the Lyso-Tag system in which he has tagged a lysosome resident transmembrane protein  termed TMEM192 with an externally facing 3 x HA tag.  This permits isolations of intact lysosome to be undertaken in under 10 min of cell lysis.  This has revolutionised our ability to study the lysosome.  Monther has been able to undertake high resolution mass spectrometry of proteins and metabolites associated with this organelle ± stimulations. He has also made knock-in mice expressing the lyso-tag that can be crossed with other disease mutant animals so how pathways that effect lysosome can be analysed. For more details on Monther's research see. https://www.abu-remaileh.com/