University of Dundee

"Crosstalk between proliferation and mechanical forces at cell and tissue scales"

Event Date: 
Thursday, May 9, 2019 - 14:00 to 15:00
Event Location: 
CTIR Sir Kenneth and Lady Noreen Murray Seminar Room
Host: 
Dr David Murray
Event Speaker: 
Yohanns Bellaïche
Institution: 
Polarity Division Morphogenesis Institut Curie
Event Type: 
Seminar
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Abstract

During development, the formation of tissues and organs entails both changes in cell shape and proliferation. Live-imaging has beautifully shown the exquisite coordination between these two processes that leads to the formation of tissues and organs with a given cell number and shape. During my talk, I will present our recent results on the interactions and feedback between morphogenesis and cell cycle progression. At the cellular level, I will show how cytokinesis forces are coordinated with the remodelling of the adherent junctions to ensure the maintenance and dynamics of epithelial cells. At the tissue scale, I will describe how global morphogenetic forces and cell geometry are integrated to regulate the cell numbers of tissues. These latter results stem from the development of recent interdisciplinary approaches providing a general framework for the study of cell division and tissue dynamics.