University of Dundee

‘Molecular Dissection of Parkinson’s Disease’

Event Date: 
Tuesday, February 13, 2018 - 13:00
Event Location: 
CTIR Sir Kenneth and Lady Noreen Murray Seminar Room
Professor Julian Blow FRSE FMedSci
Event Speaker: 
Professor Zhuohua Zhang
Central South University (CSU), China
Event Type: 

It is well documented that both genetic and environmental factors play important roles in etiology of Parkinson disease (PD). Genetic studies of familial cases identify mutations in 15 genes causing PD.  The pathophysiological function of these genes remains largely unknown. Moreover, a number of pesticides and herbicides induce parkinsonism in both human and animal models. Neurotoxins impair mitochondrial function. Some of them are also shown to affect functions of PD associated genes. Nevertheless, effects of gene-environment interaction on PD etiology are poorly studied. In this presentation, we will discuss pathophysiological effects of PD associated genetic mutations and epigenetic modifications




Abstract to follow