University of Dundee

"Nucleolin functions and targeting in tumor angiogenesis"

Event Date: 
Tuesday, July 22, 2014 - 16:00
Event Location: 
WTB Seminar Rooms
Professor Mike Stark FRSB
Event Speaker: 
Ilaria Cascone, Associate Professor in Cell Biology
Université Paris-Est Créteil Val de Marne
Event Type: 

"Nucleolin (NCL) is a highly conserved nucleocytoplasmic multifunctional protein predominantly localized at nucleolus where it control rRNA transcription. It regulates ribosome biogenesis and cytoplasmic transport
and in the cytoplasm it is involved in mRNA stability of specific genes such as Bcl2. Interestingly nucleolin localizes to the cell surface in proliferating cells and it is a marker for tumor cells and angiogenic
vessels. For this reason,cell-surface NCL has become a target for anti-cancer therapy. In our laboratory we are interested in the role of cell surface nucleolin in tumor growth and angiogenesis. We have recently
developed a several multivalent pseudopeptides family NUCANT for NCL and Nucleophosmin antagonist. Among these, N6L peptide, which strongly inhibits human tumor growth by inducing apoptosis of tumor cells (1), is currently in phase II clinical trial for cancer. We investigate the effects of NUCANT on tumor angiogenesis in a mouse model of pancreatic ductal adenocarcinoma (PDAC) (2) and a model of pancreatic euroendocrine
tumors (RipTag2)."