The gastrointestinal system is one of the major sites of immunological challenge to the host immune system. Here, the host must be able to mount protective immune responses against invading pathogenic micro-organisms but not against dietary antigens or normal beneficial enteric flora. The Powrie group are interested in the factors that control the normal mutualistic relationship between commensal bacteria and the intestinal immune system and how this breaks down in inflammatory bowel disease. In particular, T cell:dendritic cell interactions and cytokine networks in the intestine are studies both in model systems of intestinal inflammation and colon cancer and in inflammatory bowel disease (IBD) patients.
"Gut reactions: Immune pathways in the intestine in health and disease."
Wednesday, March 30, 2011 - 16:00 to 17:00
WTB Seminar Rooms
TIG / CBI Professor Fiona Powrie
Sir William Dunn School of Pathology and the Translational Gastroenterology Unit, University of Oxford