Bos, J. I. B., Armstrong, M. R., Gilroy, E. M., Boevink, P. C., Hein, I., Taylor, R. M., Tian, Z. D., Engelhardt, S., Vetukuri, R. R., Harrower, B., Dixelius, C., Bryan, G., Sadanandom, A., Whisson, S. C., Kamoun, S. and Birch, P. R. J. (2010) Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1. Proceedings of the National Academy of Sciences of the United States of America, 107, 9909-9914.
28 Oct 2020Earlier this month, Julia Wcislo was named runner-up in the Medical Research Council’s Max Perutz Science Writing Award at their virtual award ceremony. Julia...
26 Oct 2020National UK SPINE initiative created to help us stay healthy in later years Innovative research aims to target the processes behind ageing rather than treating...
19 Oct 2020Latest research from Greg Findlay’s lab in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU) is published today in Developmental Cell. The work...
19 Oct 2020Two life sciences researchers have been awarded Future Leaders Fellowships from UK Research and Innovation (UKRI). Dr Megan Bergkessel, Principal Investigator...
- “Cell colonies as active fluids: From bacterial bi...
- Join Zoom Meeting https://us02web.zoom.us/j/569695638?pwd=VG82WW9MVWlvNlhGT2FTU1ltKzJpdz09
- "Mapping resistances to viruses in cereals...
Assay Development Scientist (Biochemistry) / Enzymologist: Wellcome Centre for Anti-Infectives ResearchDrug Discovery UnitClosing Date:09 Nov 2020
Drug Discovery UnitClosing Date:11 Nov 2020
Medical Research Council Protein Phosphorylation and Ubiquitylation UnitClosing Date:13 Nov 2020
Biological ServicesClosing Date:13 Nov 2020
Boevink, P. C., Birch, P. R. and Whisson, S. C. (2011) Imaging fluorescently tagged Phytophthora effector proteins inside infected plant tissue. Methods Mol Biol, 712, 195-209. PMID: 21359810
Gilroy, E. M., Taylor, R. M., Hein, I., Boevink, P., Sadanandom, A. and Birch, P. R. (2011) CMPG1-dependent cell death follows perception of diverse pathogen elicitors at the host plasma membrane and is suppressed by Phytophthora infestans RXLR effector AVR3a. New Phytol, 190, 653-666. PMID: 21348873
Birch, P. R. J., Bryan, G., Fenton, B., Gilroy, E. M., Hein, I., Jones, J., Taylor, M., Torrance, L. and Toth, I. K. (2012) Re-localisation of late blight resistance protein R3a to endosomal compartments is associated with effector recognition and required for the immune response. Food Security. 4, 477-508
Lilley, D.M.J. (2008) DNA Junctions and their Interaction with Resolving Enzymes In Protein-Nucleic Acid Interactions: Structural Biology [Eds Rice, P.A. and Correll, C.C.] RSC publications, 129-149.
Déclais, A.C., and Lilley, D.M.J. (2008) New insight into the recognition of branched DNA structure by junction-resolving enzymes Curr. Opin. Struct. Biol. 18, 86-95.
Lilley, D.M.J. (2008) Four-way helical junctions in DNA molecules in Mathematics of DNA Structure, Function, and Interactions. IMA In press.
Aranda-Orgilles, B., Rutschow, D., Zeller, R., Karagiannidis, A. I., Kohler, A., Chen, C., Wilson, T., Krause, S., Roepcke, S., Lilley, D., Schneider, R. and Schweiger, S. (2011) Protein Phosphatase 2A (PP2A)-specific Ubiquitin Ligase MID1 Is a Sequence-dependent Regulator of Translation Efficiency Controlling 3-Phosphoinositide-dependent Protein Kinase-1 (PDPK-1). The Journal of biological chemistry. 286, 39945-39957
Araki, L., Morita, K., Yamaguchi, M., Zhao, Z. Y., Wilson, T. J., Lilley, D. M. J. and Harusawa, S. (2009) Synthesis of Novel C4-Linked C-2-Imidazole Ribonucleoside Phosphoramidite and Its Application to Probing the Catalytic Mechanism of a Ribozyme. Journal of Organic Chemistry. 74, 2350-2356
Lilley, D. M. J. (2009) Comparative gel electrophoresis analysis of helical junctions in RNA. Methods in Enzymology, Vol 469: Biophysical, Chemical, and Functional Probes of Rna Structure, Interactions and Folding, Pt B. 469, 143-157
Karnchanatat, A., Petsom, A., Sangvanich, P., Piapukiew, J., Whalley, A.J.S., Reynolds, C.D., Gadd, G.M., and Sihanonth, P. (2008) A novel thermostable endoglucanase from the wood-decaying fungus Daldinia eschscholzii (Ehrenb.:Fr.) Rehm. Enzyme and Microbial Technology 42, 404–413.
Fomina, M., Charnock, J.M., Hillier, S., Alvarez, R., Francis Livens, F., and Gadd, G.M. (2008) Role of fungi in the biogeochemical fate of depleted uranium. Current Biology 18, R375-R377.
Andrell, J., Hicks, M. G., Palmer, T., Carpenter, E. P., Iwata, S. and Maher, M. J. (2009) Crystal Structure of the Acid-Induced Arginine Decarboxylase from Escherichia coli: Reversible Decamer Assembly Controls Enzyme Activity. Biochemistry. 48, 3915-3927
Coulthurst, S. J. and Sargent, F. (2009) Chaperone-signal peptide interactions on the Tat protein transport pathway. Febs Journal. 276, 3-3
Ahmed, R. Z., Gadd, G. M. and Ahmed, N. (2010) Isolation of two Kocuria species capable of growing on various polycyclic aromatic hydrocarbons. African Journal of Biotechnology, 9, 3611-3617.
Borodkin, V. S. and van Aalten, D. M. (2010) An efficient and versatile synthesis of GlcNAcstatins-potent and selective O-GlcNAcase inhibitors built on the tetrahydroimidazo[1,2-a]pyridine scaffold. Tetrahedron, 66, 7838-7849.
Bauer, J., Fritsch, M. J., Palmer, T. and Unden, G. (2011) Topology and accessibility of the transmembrane helices and the sensory site in the bifunctional transporter DcuB of Escherichia coli. Biochemistry. 50, 5925-5938