University of Dundee

Associate Scientist, Synthetic and Medicinal Chemistry, UoD-Boehringer Ingelheim PROTAC drug discovery.

Unit: 
Centre for Targeted Protein Degradation
Job Reference: 
SLSC1089
Closing Date: 
Monday, June 27, 2022
Salary: 
£29,614 - £32,344

We are seeking to appoint an Associate Scientist, Synthetic and Medicinal Chemistry to join a multi-disciplinary drug discovery team engaged in structure-based PROTAC design in a major long-standing collaboration between the group of Professor Alessio Ciulli, University of Dundee and Boehringer Ingelheim. The joint team’s mission is to discover novel small-molecule degraders to treat cancers with serious unmet medical needs. The successful candidate will support the on-going discovery efforts of this collaboration team, as well as of the wider Centre for Targeted Protein Degradation (CeTPD).

This is an exceptional opportunity to develop synthetic organic and medicinal chemistry skills alongside experienced professionals, on high profile drug discovery projects. It is expected that as part of the role the successful candidate will be fully involved in all aspects of project team life including travelling for in-person meetings with collaborators. The role be varied, with exposure to a range of projects and opportunities for short placements in other disciplines within the collaboration team such as cell biology and structural biophysics.

About the Centre for Targeted Protein Degradation (CeTPD)

This position will be embedded within our expanding CeTPD due to open in mid 2022. The goal of CeTPD is to innovate the next-generation of small-molecule platforms and modalities to advance chemical and biological insights and therapeutic targets related to human diseases. It aspires to achieve this by openly collaborating with academic, industrial and venture partners, and by training and inspiring the next-generation of research scientists and leaders.

Role Responsibilities:
  • Independently perform routine synthetic and analytical chemistry experiments.
  • Develop new synthetic routes to access project critical intermediates or final compounds.
  • Maintain clear and accurate records of experimental work (e.g., experimental methods, results/findings).
  • Critically analyse biological data to inform new PROTAC design.
  • Prepare presentations and present updates and research outcomes at both internal CeTPD meetings and external meetings with collaborators.
Location

The postholder will be based at the newly refurbished CeTPD Complex, adjacent to the Life Sciences Complex.

Duration

The position is fixed-term, until 31st December 2023.
Candidate Requirements:

Essential

  • Qualified to at least chemistry masters degree level (MSci or MChem) or equivalent and have proven relevant experience.
  • Experience working in a synthetic organic chemistry laboratory.
  • Proven ability to perform routine organic synthesis and relevant analytics (e.g. LCMS, NMR)
  • Strong liaison skills with a wide range of individuals
  • Ability to clearly communicate complex, specialist information both orally and in writing
  • Proficient in the use of databases to maintain accurate records.
  • Excellent communication and organisational skills
  • Excellent interpersonal skills, including evidence of team working and the ability to be proactive in responding to the needs of the team

Desirable

  • First Class/Upper Second Class undergraduate qualification or equivalent
  • Previous experience in an industrial setting
  • Experience working in a results/data driven team.
  • Awareness of medicinal chemistry design principles.
  • Fundamental knowledge of targeted protein degradation approaches.
  • Capable of prioritising own workload
Commitment to DORA

The School of Life Sciences has been fully committed to the principals of the San Francisco Declaration on Research Assessment (DORA) since 2013. In assessing applicants, we consider the scientific quality of their published research papers, but do not take into account where the papers were published and do not consider journal-based metrics, such as Journal Impact Factors.
Informal enquiries may be made to Dr. William Farnaby, e-mail: w.farnaby@dundee.ac.uk or Prof. Alessio Ciulli, e-mail a.ciulli@dundee.ac.uk
 
Additional Information 

The new Centre for Targeted Protein Degradation, embedded within the University of Dundee’s School of Life Sciences, is part of a growing Life Sciences Innovation District driving innovation and economic growth in Dundee. As an internationally diverse institution, we welcome job applicants from all countries and nationalities. Family friendly policies, staff support networks for BME and LGBT staff, membership of Athena Swan and Stonewall, as well a full range of disability services, create an enjoyable and inclusive place to work.

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