University of Dundee

Chemical Biology Laboratory Assistant

Unit: 
Medical Research Council Protein Phosphorylation and Ubiquitylation Unit
Job Reference: 
SLSC1092
Closing Date: 
Thursday, July 14, 2022
Salary: 
£27,116 to £37,467
The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 40 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.
 
Applications are invited for a scientist to support pioneering ubiquitin research at the interface of chemistry and biology. The ubiquitin system regulates virtually all aspects of the cell and has strong links to disease and drug development.
 
The successful candidate will gain experience with powerful protein engineering technologies including chemical protein synthesis and genetic code expansion. These will be applied to further develop and optimise the production of protein-based probe molecules that have enabled breakthrough discoveries in ubiquitin system research (Pao et al. Nat Chem Biol., 2016; Pao et al. Nature 2018; Mathur et al. Cell Chem Biol. 2020). The candidate will be based in the lab of Prof. Satpal Virdee and will also support exciting research from the lab of Prof. Doreen Cantrell FRS on the role of ubiquitin conjugation enzymes in immune signalling.
 
Motivated individuals who have recently graduated or obtained a PhD in chemistry or biochemistry with lab experience are encouraged to apply. The position will be a fantastic opportunity for the candidate to broaden their skill set by working between internationally renowned labs using state-of-the-art multidisciplinary technologies.

The position is available for an immediate start and is fixed-term for 12 months in the first instance, with the possibility of a further extension.

Salary will depend upon experience, with the appointment being made at either Grade 6 or Grade 7 on the University's salary scales (from £27,116 to £37,467). Appointment on the Grade 7 salary scale is dependent upon you having been awarded a PhD.

For informal enquiries please contact Prof. Virdee directly at s.s.virdee@dundee.ac.uk
Role Responsibility:
  • Express and purify recombinant proteins
  • Prepare protein-based probes using an established semisynthetic procedure
  • Carry our QC analysis of prepared material
  • Carry out method optimisation

For appointment at Grade 7, in addition to the above you will also:

  • Develop novel assay formats
  • Train and supervise new lab members
Who we’re looking for:
  • A degree or PhD in chemistry, biochemistry or a related chemical science
  • Excellent technical and organisational skills
  • Capable of working in a team, but able to plan and work independently
  • Strong communication skills
Commitment to DORA

The School of Life Sciences has been fully committed to the principals of the San Francisco Declaration on Research Assessment (DORA) since 2013. In assessing applicants, we consider the scientific quality of their published research papers, but do not take into account where the papers were published and do not consider journal-based metrics, such as Journal Impact Factors.
 
We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we’re close to both the train and bus stations. We also have campuses at Ninewells Hospital and in Kirkcaldy which are easily accessible via local transport links.
 

The MRC-PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation (http://www.ppu.mrc.ac.uk) and has an exciting and collaborative research environment, equipped to the highest international standards. The major aims of the MRC-PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease; to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation; and to generate reagents and improve technologies. Another key remit of the MRC-PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research. The MRC-PPU is located in a beautiful setting overlooking the estuary of the River Tay and embedded within the School of Life Sciences at the University of Dundee.

 

As an internationally diverse institution, we welcome job applicants from all countries and nationalities. The School of Life Sciences is proud to employ staff from over 40 different nations.

 

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

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