Summary of Job Purpose and Principal Duties:
Therapeutically activating autophagy in vivo
We are seeking a talented postdoctoral fellow to be involved in the development of pharmacological activators of autophagy and to identify new biology in this area. Work will be carried out in the laboratory of Ian Ganley at the Medical Research Council’s Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU) in Dundee. This is part of a unique academic-industrial collaboration led by Samsara Therapeutics.
Autophagy is a cell protective process and its dysregulation has been linked to many diseases, including cancer and neurodegeneration. Given this, autophagy-based therapies have now emerged as an attractive target area and the successful candidate will have the exciting opportunity to significantly contribute to developing such an approach. Using candidate autophagy-activating compounds, we will use state-of-the-art models that allow comparative analyses of autophagy and mitophagy in vivo (PMID: 27458135, 29337137, 34340748). With these, the successful candidate will utilise pharmacology and genetics, combined with high-resolution microscopy and biochemistry, to determine when and where autophagy and mitophagy are activated in vivo.
- PhD with outstanding academic record and at least one first authored publication in a recognised peer-reviewed journal.
- Strong background in animal models and cell biology would be beneficial.
- Capable of working in a team, but able to plan and work independently.
- Excellent communication skills and knowledge of the English language.
The position is initially available for 2 years. Salary will depend on experience, but the appointment will be made on the University's Grade 7 salary scale.
An appointment may be considered if you are shortly expected to be awarded a PhD. In this case the initial appointment would be made as a Research Assistant on the Training Grade 7 salary scale.
MRC Protein Phosphorylation and Ubiquitylation Unit (PPU)
The successful applicant will have the opportunity to work in an exciting and collaborative research environment, equipped to the highest international standards. The MRC-PPU is in a beautiful location overlooking the River Tay and embedded within the School of Life Sciences at the University of Dundee: one of the premier life sciences research centres in the world. For further details consult: http://www.ppu.mrc.ac.uk
Samsara’s mission is to discover new mechanisms which can restore autophagy, and at the same time new drugs which use these mechanisms for the treatment of genetically defined diseases. Our scientific co-founders Professor Guido Kroemer and Professor Frank Madeo are world leaders in the fields of geroscience and cellular homeostasis. For further details consult: https://www.samsaratherapeutics.com/
The University's statement on the use of animals in research can be found here:
As an internationally diverse institution, we welcome job applicants from all countries and nationalities. The School of Life Sciences is proud to employ staff from over 40 different nations.
The international diversity of our staff and students helps to make the University of Dundee one of the top universities in the UK. Family friendly policies, staff support networks for BME and LGBT staff, membership of Athena Swan and Stonewall, as well a full range of disability services, create an enjoyable and inclusive place to work.
The Closing Date is 8th October 2021
For further information or to apply for this position please click here